The functions of the nuclear envelope in mediating the molecular crosstalk between the nucleus and the cytoplasm

Takeshi Shimi, Veronika Butin-Israeli, Robert D. Goldman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

30 Scopus citations

Abstract

Recent studies of the nuclear envelope (NE) have emphasized its role in linking the nuclear and cytoplasmic compartments of mammalian cells. The inner face of the NE is bound to chromatin and this interaction is involved in regulating DNA replication and transcription. The outer face of the NE binds to different components of the cytoskeleton, and these interactions are involved in nuclear positioning. Many disease causing mutations in genes encoding NE proteins cause significant changes in nuclear architecture and cytoskeletal interactions with the NE. These mutations are also providing important new insights into nuclear-cytoplasmic interactions.

Original languageEnglish (US)
Pages (from-to)71-78
Number of pages8
JournalCurrent Opinion in Cell Biology
Volume24
Issue number1
DOIs
StatePublished - Feb 2012

ASJC Scopus subject areas

  • Cell Biology

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