The gene for incontinentia pigmenti: failure of linkage studies using DNA probes to confirm cytogenetic localization

Ann Harris; Shelley Lankester; Eric Haan; Judith Beres; Maj Hulten; Judit Szollar; Linda Soutter; Martin Bobrow

doi:10.1111/j.1399-0004.1988.tb02607.x

The gene for incontinentia pigmenti: failure of linkage studies using DNA probes to confirm cytogenetic localization

Ann Harris^*, Shelley Lankester, Eric Haan, Judith Beres, Maj Hulten, Judit Szollar, Linda Soutter, Martin Bobrow

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Probes for restriction fragment length polymorphisms mapping between Xp21 and Xq22.3 have been used in a linkage study of incontinentia pigmenti (IP). Six independent sporadic cases of disorders resembling IP with X‐autosome translocations involving the same X chromosome breakpoint (Xp11) have been reported. These observations suggest that the IP gene may be located in the Xp11 chromosomal region. However, the linkage study with DNA probes has failed to confirm this localisation.

Original language	English (US)
Pages (from-to)	1-6
Number of pages	6
Journal	Clinical Genetics
Volume	34
Issue number	1
DOIs	https://doi.org/10.1111/j.1399-0004.1988.tb02607.x
State	Published - Jul 1988

Keywords

DNA probes
incontinentia pigmenti
linkage

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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10.1111/j.1399-0004.1988.tb02607.x

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AU - Szollar, Judit

AU - Soutter, Linda

AU - Bobrow, Martin

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AB - Probes for restriction fragment length polymorphisms mapping between Xp21 and Xq22.3 have been used in a linkage study of incontinentia pigmenti (IP). Six independent sporadic cases of disorders resembling IP with X‐autosome translocations involving the same X chromosome breakpoint (Xp11) have been reported. These observations suggest that the IP gene may be located in the Xp11 chromosomal region. However, the linkage study with DNA probes has failed to confirm this localisation.

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KW - linkage

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The gene for incontinentia pigmenti: failure of linkage studies using DNA probes to confirm cytogenetic localization

Abstract

Keywords

ASJC Scopus subject areas

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