The Genetic Architecture of Parkinson Disease in Spain: Characterizing Population-Specific Risk, Differential Haplotype Structures, and Providing Etiologic Insight

Keyphrases

• Parkinson's Disease 100%
• High-risk HPV 100%
• Population Specificity 100%
• Specific Risk 100%
• Genetic Architecture 100%
• Spain 100%
• Haplotype Structure 100%
• Risk Differential 100%
• Genome-wide Association Study 66%
• Age of Onset 66%
• Expression Data 66%
• Methylation Data 66%
• PARK2 66%
• Functional Consequences 33%
• Diverse Populations 33%
• Neurodegenerative Diseases 33%
• Disease-associated 33%
• Etiology 33%
• Genetic Studies 33%
• Complex Disease 33%
• Machine Learning 33%
• Fine Mapping 33%
• Leucine-rich Repeat Kinase 2 (LRRK2) 33%
• Substructure 33%
• Further Analysis 33%
• Unique Populations 33%
• Novel Population 33%
• Population Admixture 33%
• Mendelian Randomization 33%
• Polygenic Risk Score 33%
• Gene Locus 33%
• HLA-DQB1 33%
• Runs of Homozygosity 33%
• Population History 33%
• Significant Trend 33%
• Heritability Estimates 33%
• Iberian Peninsula 33%
• Mendelian Randomization Analysis 33%
• Burden Analysis 33%
• Genetic Burden 33%
• PD-related Genes 33%
• KANSL1 33%
• Genetic Correlation Analysis 33%
• Population Isolation 33%

Biochemistry, Genetics and Molecular Biology

• Haplotype 100%
• Genetic Architecture 100%
• Methylation 50%
• Mendelian Randomization 50%
• Genome-Wide Association Study 50%
• LRRK2 25%
• Genetic Correlation 25%
• Genetics 25%
• Genome Wide Association Study 25%
• Gene Locus 25%
• Runs Of Homozygosity 25%
• HLA-DQB1 25%