The genetic basis of variability in drug responses

Dan M. Roden*, Alfred L. George

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

229 Scopus citations


It is almost axiomatic that patients vary widely in their beneficial responses to drug therapy, and serious and apparently unpredictable adverse drug reactions continue to be a major public health problem. Here, we discuss the concept that genetic variants might determine much of this variability in drug response, and propose an algorithm to enable further evaluation of the benefits and pitfalls of this enticing possibility.

Original languageEnglish (US)
Pages (from-to)37-44
Number of pages8
JournalNature Reviews Drug Discovery
Issue number1
StatePublished - Jan 2002

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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