The genetic landscape of mutations in Burkitt lymphoma

Cassandra Love; Zhen Sun; Dereje Jima; Guojie Li; Jenny Zhang; Rodney Miles; Kristy L. Richards; Cherie H. Dunphy; William L. Choi; Gopesh Srivastava; Patricia L. Lugar; David A. Rizzieri; Anand S. Lagoo; Leon Bernal-Mizrachi; Karen P. Mann; Christopher R. Flowers; Kikkeri N. Naresh; Andrew M. Evens; Amy Chadburn; Leo I. Gordon; Magdalena B. Czader; Javed I. Gill; Eric D. Hsi; Adrienne Greenough; Andrea B. Moffitt; Matthew McKinney; Anjishnu Banerjee; Vladimir Grubor; Shawn Levy; David B. Dunson; Sandeep S. Dave

doi:10.1038/ng.2468

The genetic landscape of mutations in Burkitt lymphoma

Cassandra Love, Zhen Sun, Dereje Jima, Guojie Li, Jenny Zhang, Rodney Miles, Kristy L. Richards, Cherie H. Dunphy, William L. Choi, Gopesh Srivastava, Patricia L. Lugar, David A. Rizzieri, Anand S. Lagoo, Leon Bernal-Mizrachi, Karen P. Mann, Christopher R. Flowers, Kikkeri N. Naresh, Andrew M. Evens, Amy Chadburn, Leo I. GordonMagdalena B. Czader, Javed I. Gill, Eric D. Hsi, Adrienne Greenough, Andrea B. Moffitt, Matthew McKinney, Anjishnu Banerjee, Vladimir Grubor, Shawn Levy, David B. Dunson, Sandeep S. Dave^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

477 Scopus citations

Abstract

Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequenced the exomes of 59 Burkitt lymphoma tumors and compared them to sequenced exomes from 94 diffuse large B-cell lymphoma (DLBCL) tumors. We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3, GNA13, RET, PIK3R1 and the SWI/SNF genes ARID1A and SMARCA4. Our data implicate a number of genes in cancer for the first time, including CCT6B, SALL3, FTCD and PC. ID3 mutations occurred in 34% of Burkitt lymphomas and not in DLBCLs. We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene.

Original language	English (US)
Pages (from-to)	1321-1325
Number of pages	5
Journal	Nature Genetics
Volume	44
Issue number	12
DOIs	https://doi.org/10.1038/ng.2468
State	Published - Dec 2012

Funding

The authors thank S. Sunay and the Georgia Cancer Coalition for support in sample collection. A.B.M. was supported by the Hertz Foundation. This work was supported through grants R21CA1561686 and R01CA136895 from the National Cancer Institute (S.S.D.). S.S.D. was also supported by the American Cancer Society. We gratefully acknowledge the generous support of C. Stiefel and D. Stiefel.

ASJC Scopus subject areas

Genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Love, C., Sun, Z., Jima, D., Li, G., Zhang, J., Miles, R., Richards, K. L., Dunphy, C. H., Choi, W. L., Srivastava, G., Lugar, P. L., Rizzieri, D. A., Lagoo, A. S., Bernal-Mizrachi, L., Mann, K. P., Flowers, C. R., Naresh, K. N., Evens, A. M., Chadburn, A., ... Dave, S. S. (2012). The genetic landscape of mutations in Burkitt lymphoma. Nature Genetics, 44(12), 1321-1325. https://doi.org/10.1038/ng.2468

@article{342081bec22343ab93bb3f2caf7cc390,

title = "The genetic landscape of mutations in Burkitt lymphoma",

abstract = "Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequenced the exomes of 59 Burkitt lymphoma tumors and compared them to sequenced exomes from 94 diffuse large B-cell lymphoma (DLBCL) tumors. We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3, GNA13, RET, PIK3R1 and the SWI/SNF genes ARID1A and SMARCA4. Our data implicate a number of genes in cancer for the first time, including CCT6B, SALL3, FTCD and PC. ID3 mutations occurred in 34% of Burkitt lymphomas and not in DLBCLs. We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene.",

author = "Cassandra Love and Zhen Sun and Dereje Jima and Guojie Li and Jenny Zhang and Rodney Miles and Richards, {Kristy L.} and Dunphy, {Cherie H.} and Choi, {William L.} and Gopesh Srivastava and Lugar, {Patricia L.} and Rizzieri, {David A.} and Lagoo, {Anand S.} and Leon Bernal-Mizrachi and Mann, {Karen P.} and Flowers, {Christopher R.} and Naresh, {Kikkeri N.} and Evens, {Andrew M.} and Amy Chadburn and Gordon, {Leo I.} and Czader, {Magdalena B.} and Gill, {Javed I.} and Hsi, {Eric D.} and Adrienne Greenough and Moffitt, {Andrea B.} and Matthew McKinney and Anjishnu Banerjee and Vladimir Grubor and Shawn Levy and Dunson, {David B.} and Dave, {Sandeep S.}",

note = "Funding Information: The authors thank S. Sunay and the Georgia Cancer Coalition for support in sample collection. A.B.M. was supported by the Hertz Foundation. This work was supported through grants R21CA1561686 and R01CA136895 from the National Cancer Institute (S.S.D.). S.S.D. was also supported by the American Cancer Society. We gratefully acknowledge the generous support of C. Stiefel and D. Stiefel.",

year = "2012",

month = dec,

doi = "10.1038/ng.2468",

language = "English (US)",

volume = "44",

pages = "1321--1325",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "12",

}

Love, C, Sun, Z, Jima, D, Li, G, Zhang, J, Miles, R, Richards, KL, Dunphy, CH, Choi, WL, Srivastava, G, Lugar, PL, Rizzieri, DA, Lagoo, AS, Bernal-Mizrachi, L, Mann, KP, Flowers, CR, Naresh, KN, Evens, AM, Chadburn, A, Gordon, LI, Czader, MB, Gill, JI, Hsi, ED, Greenough, A, Moffitt, AB, McKinney, M, Banerjee, A, Grubor, V, Levy, S, Dunson, DB & Dave, SS 2012, 'The genetic landscape of mutations in Burkitt lymphoma', Nature Genetics, vol. 44, no. 12, pp. 1321-1325. https://doi.org/10.1038/ng.2468

TY - JOUR

T1 - The genetic landscape of mutations in Burkitt lymphoma

AU - Love, Cassandra

AU - Sun, Zhen

AU - Jima, Dereje

AU - Li, Guojie

AU - Zhang, Jenny

AU - Miles, Rodney

AU - Richards, Kristy L.

AU - Dunphy, Cherie H.

AU - Choi, William L.

AU - Srivastava, Gopesh

AU - Lugar, Patricia L.

AU - Rizzieri, David A.

AU - Lagoo, Anand S.

AU - Bernal-Mizrachi, Leon

AU - Mann, Karen P.

AU - Flowers, Christopher R.

AU - Naresh, Kikkeri N.

AU - Evens, Andrew M.

AU - Chadburn, Amy

AU - Gordon, Leo I.

AU - Czader, Magdalena B.

AU - Gill, Javed I.

AU - Hsi, Eric D.

AU - Greenough, Adrienne

AU - Moffitt, Andrea B.

AU - McKinney, Matthew

AU - Banerjee, Anjishnu

AU - Grubor, Vladimir

AU - Levy, Shawn

AU - Dunson, David B.

AU - Dave, Sandeep S.

N1 - Funding Information: The authors thank S. Sunay and the Georgia Cancer Coalition for support in sample collection. A.B.M. was supported by the Hertz Foundation. This work was supported through grants R21CA1561686 and R01CA136895 from the National Cancer Institute (S.S.D.). S.S.D. was also supported by the American Cancer Society. We gratefully acknowledge the generous support of C. Stiefel and D. Stiefel.

PY - 2012/12

Y1 - 2012/12

N2 - Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequenced the exomes of 59 Burkitt lymphoma tumors and compared them to sequenced exomes from 94 diffuse large B-cell lymphoma (DLBCL) tumors. We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3, GNA13, RET, PIK3R1 and the SWI/SNF genes ARID1A and SMARCA4. Our data implicate a number of genes in cancer for the first time, including CCT6B, SALL3, FTCD and PC. ID3 mutations occurred in 34% of Burkitt lymphomas and not in DLBCLs. We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene.

AB - Burkitt lymphoma is characterized by deregulation of MYC, but the contribution of other genetic mutations to the disease is largely unknown. Here, we describe the first completely sequenced genome from a Burkitt lymphoma tumor and germline DNA from the same affected individual. We further sequenced the exomes of 59 Burkitt lymphoma tumors and compared them to sequenced exomes from 94 diffuse large B-cell lymphoma (DLBCL) tumors. We identified 70 genes that were recurrently mutated in Burkitt lymphomas, including ID3, GNA13, RET, PIK3R1 and the SWI/SNF genes ARID1A and SMARCA4. Our data implicate a number of genes in cancer for the first time, including CCT6B, SALL3, FTCD and PC. ID3 mutations occurred in 34% of Burkitt lymphomas and not in DLBCLs. We show experimentally that ID3 mutations promote cell cycle progression and proliferation. Our work thus elucidates commonly occurring gene-coding mutations in Burkitt lymphoma and implicates ID3 as a new tumor suppressor gene.

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U2 - 10.1038/ng.2468

DO - 10.1038/ng.2468

M3 - Article

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AN - SCOPUS:84870538715

SN - 1061-4036

VL - 44

SP - 1321

EP - 1325

JO - Nature Genetics

JF - Nature Genetics

IS - 12

ER -

The genetic landscape of mutations in Burkitt lymphoma

Abstract

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ASJC Scopus subject areas

UN SDGs

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