TY - JOUR
T1 - The genetics of mammalian circadian order and disorder
T2 - Implications for physiology and disease
AU - Takahashi, Joseph S.
AU - Hong, Hee Kyung
AU - Ko, Caroline H.
AU - McDearmon, Erin L.
N1 - Funding Information:
Acknowledgements We thank the anonymous reviewers for their editorial suggestions. Research is supported by grants from the National Institutes of Health (U01 MH61915 and R01 MH078024) and a Silvio O. Conte Center grant (P50 MH074924) to J.S.T. J.S.T. is an Investigator in the Howard Hughes Medical Institute.
PY - 2008/10
Y1 - 2008/10
N2 - Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.
AB - Circadian cycles affect a variety of physiological processes, and disruptions of normal circadian biology therefore have the potential to influence a range of disease-related pathways. The genetic basis of circadian rhythms is well studied in model organisms and, more recently, studies of the genetic basis of circadian disorders has confirmed the conservation of key players in circadian biology from invertebrates to humans. In addition, important advances have been made in understanding how these molecules influence physiological functions in tissues throughout the body. Together, these studies set the scene for applying our knowledge of circadian biology to the understanding and treatment of a range of human diseases, including cancer and metabolic and behavioural disorders.
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U2 - 10.1038/nrg2430
DO - 10.1038/nrg2430
M3 - Review article
C2 - 18802415
AN - SCOPUS:52149109334
SN - 1471-0056
VL - 9
SP - 764
EP - 775
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
IS - 10
ER -
