The genetics of sleep: Insight from rodent models

Keith C. Summa, Fred W. Turek

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

Sleep is a fundamental behavior in higher animals that is under substantial genetic control. Genetic studies in animal models have uncovered genomic loci associated with specific traits, validated the key role of neurotransmitter systems in sleep-wake regulation, identified genes responsible for controlling sleep-wake traits, and demonstrated genetic overlap in the regulation of sleep and circadian rhythms. Future studies are expected to reveal additional genes and gene networks underlying certain sleep-wake traits, advancing understanding of the molecular basis of sleep, which may suggest answers to the question of why we sleep and provide insight into the relationship between sleep and chronic diseases.

Original languageEnglish (US)
Pages (from-to)141-154
Number of pages14
JournalSleep Medicine Clinics
Volume6
Issue number2
DOIs
StatePublished - Jun 2011

Keywords

  • Animal models
  • Circadian rhythms
  • Genetics
  • Rodents
  • Sleep

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Clinical Psychology
  • Clinical Neurology
  • Psychiatry and Mental health

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