The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease

Paul A. Agius; Julia C. Cutts; Peige Song; Igor Rudan; Diana Rudan; Victor Aboyans; Mary M. McDermott; Michael H. Criqui; F. Gerald R. Fowkes; Freya J.I. Fowkes

doi:10.1007/s44197-022-00049-1

The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease

Paul A. Agius, Julia C. Cutts, Peige Song, Igor Rudan, Diana Rudan, Victor Aboyans, Mary M. McDermott, Michael H. Criqui, F. Gerald R. Fowkes, Freya J.I. Fowkes^*

^*Corresponding author for this work

Medicine, General Medicine Division

Research output: Contribution to journal › Comment/debate › peer-review

3 Scopus citations

Abstract

An epidemiological transition in the prevalence of peripheral artery disease (PAD) is taking place especially in low- and middle-income countries (LMICs) where an ageing population and adoption of western lifestyles are associated with an increase in PAD. We discuss the limited evidence which suggests that infection, potentially mediated by inflammation, may be a risk factor for PAD, and show by means of an ecological analysis that country-level prevalence of the major endemic infections of HIV, tuberculosis and malaria are associated with the prevalence of PAD. While further research is required, we propose that scientists and health authorities pay more attention to the interplay between communicable and non-communicable diseases, and we suggest that limiting the occurrence of endemic infections might have some effect on slowing the epidemiological transition in PAD.

Original language	English (US)
Pages (from-to)	219-223
Number of pages	5
Journal	Journal of Epidemiology and Global Health
Volume	12
Issue number	3
DOIs	https://doi.org/10.1007/s44197-022-00049-1
State	Published - Sep 2022

Funding

The Peripheral Arterial Disease Research Coalition (Europe) provided funds for data acquisition and analysis. This work was supported by the National Health and Medical Research Council of Australia (NHMRC) (fellowship to FJIF) and its Independent Research Institute Infrastructure Support Scheme. The authors gratefully acknowledge the contribution to this work of the Victorian Operational Infrastructure Support Program received by the Burnet Institute. The funding sources had no role in the writing of the manuscript or the decision to submit for publication. In the past three years, MMM has received research funding from Regeneron and Helixmith and other research support from Mars, Hershey, ReserveAge, Chromadex, and ArtAssist. VA has received payment from Bayer Healthcare, NovoNordisk, AstraZeneca, BoehringerIngelheim. Other authors declare no competing interests.

Keywords

Epidemiology
HIV
Malaria
Peripheral arterial disease
Tuberculosis

ASJC Scopus subject areas

Epidemiology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s44197-022-00049-1

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Agius, P. A., Cutts, J. C., Song, P., Rudan, I., Rudan, D., Aboyans, V., McDermott, M. M., Criqui, M. H., Fowkes, F. G. R., & Fowkes, F. J. I. (2022). The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease. Journal of Epidemiology and Global Health, 12(3), 219-223. https://doi.org/10.1007/s44197-022-00049-1

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title = "The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease",

abstract = "An epidemiological transition in the prevalence of peripheral artery disease (PAD) is taking place especially in low- and middle-income countries (LMICs) where an ageing population and adoption of western lifestyles are associated with an increase in PAD. We discuss the limited evidence which suggests that infection, potentially mediated by inflammation, may be a risk factor for PAD, and show by means of an ecological analysis that country-level prevalence of the major endemic infections of HIV, tuberculosis and malaria are associated with the prevalence of PAD. While further research is required, we propose that scientists and health authorities pay more attention to the interplay between communicable and non-communicable diseases, and we suggest that limiting the occurrence of endemic infections might have some effect on slowing the epidemiological transition in PAD.",

keywords = "Epidemiology, HIV, Malaria, Peripheral arterial disease, Tuberculosis",

author = "Agius, {Paul A.} and Cutts, {Julia C.} and Peige Song and Igor Rudan and Diana Rudan and Victor Aboyans and McDermott, {Mary M.} and Criqui, {Michael H.} and Fowkes, {F. Gerald R.} and Fowkes, {Freya J.I.}",

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doi = "10.1007/s44197-022-00049-1",

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Agius, PA, Cutts, JC, Song, P, Rudan, I, Rudan, D, Aboyans, V, McDermott, MM, Criqui, MH, Fowkes, FGR & Fowkes, FJI 2022, 'The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease', Journal of Epidemiology and Global Health, vol. 12, no. 3, pp. 219-223. https://doi.org/10.1007/s44197-022-00049-1

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T2 - Unrecognised Impact of Endemic Infections on Peripheral Artery Disease

AU - Agius, Paul A.

AU - Cutts, Julia C.

AU - Song, Peige

AU - Rudan, Igor

AU - Rudan, Diana

AU - Aboyans, Victor

AU - McDermott, Mary M.

AU - Criqui, Michael H.

AU - Fowkes, F. Gerald R.

AU - Fowkes, Freya J.I.

PY - 2022/9

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N2 - An epidemiological transition in the prevalence of peripheral artery disease (PAD) is taking place especially in low- and middle-income countries (LMICs) where an ageing population and adoption of western lifestyles are associated with an increase in PAD. We discuss the limited evidence which suggests that infection, potentially mediated by inflammation, may be a risk factor for PAD, and show by means of an ecological analysis that country-level prevalence of the major endemic infections of HIV, tuberculosis and malaria are associated with the prevalence of PAD. While further research is required, we propose that scientists and health authorities pay more attention to the interplay between communicable and non-communicable diseases, and we suggest that limiting the occurrence of endemic infections might have some effect on slowing the epidemiological transition in PAD.

AB - An epidemiological transition in the prevalence of peripheral artery disease (PAD) is taking place especially in low- and middle-income countries (LMICs) where an ageing population and adoption of western lifestyles are associated with an increase in PAD. We discuss the limited evidence which suggests that infection, potentially mediated by inflammation, may be a risk factor for PAD, and show by means of an ecological analysis that country-level prevalence of the major endemic infections of HIV, tuberculosis and malaria are associated with the prevalence of PAD. While further research is required, we propose that scientists and health authorities pay more attention to the interplay between communicable and non-communicable diseases, and we suggest that limiting the occurrence of endemic infections might have some effect on slowing the epidemiological transition in PAD.

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KW - HIV

KW - Malaria

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KW - Tuberculosis

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The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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