The great escape: Pseudomonas breaks out of the lung

Angelica Zhang, Stephanie M. Rangel, Alan R. Hauser*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

The Gram-negative bacterium Pseudomonas aeruginosa is a major cause of hospital-acquired infections and the focus of much attention due to its resistance to many conventional antibiotics. It harbors a wide range of disease-promoting virulence factors, including a type III secretion system. Here we review our recent study of ExoS, one of the effector proteins exported by this type III secretion system. Using a mouse model of pneumonia, we showed that the ADP-ribosyltransferase (ADPRT) activity of ExoS caused formation of “fields of cell injection” (FOCI) in the lungs. These FOCI represented ExoS-injected clusters of type I pneumocytes that became compromised, leading to disruption of the pulmonary-vascular barrier and subsequent bacterial dissemination from the lungs to the bloodstream. We discuss the potential mechanisms by which these processes occur as well as the novel techniques used to study ExoS function in vivo.

Original languageEnglish (US)
Article numbere1004945
Pages (from-to)409-411
Number of pages3
JournalMicrobial Cell
Volume2
Issue number10
DOIs
StatePublished - Oct 2015

Keywords

  • Dissemination
  • ExoS
  • Pneumonia
  • Pseudomonas aeruginosa

ASJC Scopus subject areas

  • Immunology and Microbiology (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology (miscellaneous)

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