TY - JOUR
T1 - The Great Recession and health risks in African American youth
AU - Chen, Edith
AU - Miller, Gregory E.
AU - Yu, Tianyi
AU - Brody, Gene H.
N1 - Funding Information:
The research reported in this article was supported by Grants from the National Institute of Child Health and Human Development (R01 HD030588), National Heart, Lung, and Blood Institute (R01 HL108723, HL122328), and National Institute on Drug Abuse (P30 DA027827). All authors declare no conflicts of interest.
Funding Information:
The research reported in this article was supported by Grants from the National Institute of Child Health and Human Development (R01 HD030588), National Heart, Lung, and Blood Institute (R01 HL108723, HL122328), and National Institute on Drug Abuse (P30 DA027827). All authors declare no conflicts of interest.
Publisher Copyright:
© 2015 Elsevier Inc.
PY - 2016/3/1
Y1 - 2016/3/1
N2 - In the present study, we investigated associations of macro-economic conditions - the Great Recession - with cellular epigenetic aging, allostatic load, and self-reported health, in a group that experiences significant health disparities, African Americans. A sample of 330 African American adolescents in Georgia was followed from pre-recession (2007, M age = 16.6) to post-recession (2010, M age = 19.3). Economic data were collected in both 2007 and 2010. Three groups were formed to represent economic trajectories across the period of the Great Recession (stable low economic hardship, downward mobility, and stable high economic hardship). At age 19, measures of cellular epigenetic aging (derived from leukocyte DNA methylation profiles, reflecting the disparity between a person's biological and chronological age), allostatic load (composite of blood pressure, C reactive protein, cortisol, epinephrine, norepinephrine, and body mass index), and adolescent self-report of health were obtained. Linear trend analyses documented significant differences across all outcomes. The more time adolescents spent under economic hardship, the higher their epigenetic aging [estimate = 1.421, SE = 0.466, p = .002] and allostatic load [estimate = 1.151, SE = 0.375, p = .002] scores, and the worse their self-report of health [estimate = 4.957, SE = 1.800, p = .006]. Specific group comparisons revealed that adolescents in the downward mobility group had higher levels of allostatic load than adolescents in the stable low hardship group [p < .05]. Overall, these findings suggest that the health profiles of African American youth may in part be shaped by environmental macro-economic societal conditions, and that effects on biological markers can be detected relatively early in life.
AB - In the present study, we investigated associations of macro-economic conditions - the Great Recession - with cellular epigenetic aging, allostatic load, and self-reported health, in a group that experiences significant health disparities, African Americans. A sample of 330 African American adolescents in Georgia was followed from pre-recession (2007, M age = 16.6) to post-recession (2010, M age = 19.3). Economic data were collected in both 2007 and 2010. Three groups were formed to represent economic trajectories across the period of the Great Recession (stable low economic hardship, downward mobility, and stable high economic hardship). At age 19, measures of cellular epigenetic aging (derived from leukocyte DNA methylation profiles, reflecting the disparity between a person's biological and chronological age), allostatic load (composite of blood pressure, C reactive protein, cortisol, epinephrine, norepinephrine, and body mass index), and adolescent self-report of health were obtained. Linear trend analyses documented significant differences across all outcomes. The more time adolescents spent under economic hardship, the higher their epigenetic aging [estimate = 1.421, SE = 0.466, p = .002] and allostatic load [estimate = 1.151, SE = 0.375, p = .002] scores, and the worse their self-report of health [estimate = 4.957, SE = 1.800, p = .006]. Specific group comparisons revealed that adolescents in the downward mobility group had higher levels of allostatic load than adolescents in the stable low hardship group [p < .05]. Overall, these findings suggest that the health profiles of African American youth may in part be shaped by environmental macro-economic societal conditions, and that effects on biological markers can be detected relatively early in life.
KW - Adolescent health
KW - Epigenetic aging
KW - Socioeconomic status
UR - http://www.scopus.com/inward/record.url?scp=84959572097&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84959572097&partnerID=8YFLogxK
U2 - 10.1016/j.bbi.2015.12.015
DO - 10.1016/j.bbi.2015.12.015
M3 - Article
C2 - 26718449
AN - SCOPUS:84959572097
VL - 53
SP - 234
EP - 241
JO - Brain, Behavior, and Immunity
JF - Brain, Behavior, and Immunity
SN - 0889-1591
ER -