The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Divakar S. Mithal; Navdeep S. Chandel

doi:10.1016/j.cmet.2021.09.006

The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Divakar S. Mithal, Navdeep S. Chandel^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.

Original language	English (US)
Pages (from-to)	1905-1907
Number of pages	3
Journal	Cell Metabolism
Volume	33
Issue number	10
DOIs	https://doi.org/10.1016/j.cmet.2021.09.006
State	Published - Oct 5 2021

ASJC Scopus subject areas

Molecular Biology
Physiology
Cell Biology

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10.1016/j.cmet.2021.09.006

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title = "The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease",

abstract = "Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.",

author = "Mithal, {Divakar S.} and Chandel, {Navdeep S.}",

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AU - Chandel, Navdeep S.

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N2 - Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.

AB - Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.

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The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Abstract

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