The Gro3p factor: Restoring NAD+/NADH homeostasis to ameliorate mitochondrial disease

Research output: Contribution to journalArticlepeer-review

Abstract

Leigh syndrome, a mitochondrial disease, can be modeled in mice with a deficiency in mitochondrial complex I that results in a decreased NAD+/NADH ratio. In this issue of Cell Metabolism, Liu et al. (2021) identify glycerol-3-phosphate (Gro3P) biosynthesis as a method for regenerating cytosolic NAD+ to ameliorate pathology in this mitochondrial disease model.

Original languageEnglish (US)
Pages (from-to)1905-1907
Number of pages3
JournalCell Metabolism
Volume33
Issue number10
DOIs
StatePublished - Oct 5 2021

ASJC Scopus subject areas

  • Physiology
  • Molecular Biology
  • Cell Biology

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