The hamster as an experimental animal for the study of influenza - II. The role of spleen cells in protection

R. Jennings*, J. P. Phair, M. D. Denton, C. W. Potter

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Hamsters previously infected by influenza viruses, have been shown to have a cell-mediated immune response, as measured by the macrophage migration inhibition test. The participation of spleen cells in the protection of recipients against homologous influenza virus infection was also demonstrated using adoptive transfer experiments. However, the protection achieved by spleen cell transfer was marginal and not observed in every animal. The time at which the spleen cells were transferred following infection, and their number, affected the outcome. Evidence suggesting that transferred spleen cells protected recipient hamsters through specific antibody is presented.

Original languageEnglish (US)
Pages (from-to)227-237
Number of pages11
JournalMedical Microbiology and Immunology
Volume162
Issue number3-4
DOIs
StatePublished - Dec 1 1976

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Microbiology (medical)

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