TY - JOUR
T1 - The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults with HIV (HEALTH)
T2 - A Research Protocol
AU - Oliveira, Vitor H.F.
AU - Erlandson, Kristine M.
AU - Cook, Paul F.
AU - Jankowski, Catherine
AU - Mawhinney, Samantha
AU - Dirajlal-Fargo, Sahera
AU - Knaub, Leslie
AU - Hsiao, Chao Pin
AU - Davey, Christine Horvat
AU - Webel, Allison R.
N1 - Funding Information:
This study was funded by the National Institute on Aging # R01AG066562 (PIs: A. R. Webel and K. M. Erlandson).
Publisher Copyright:
© 2022 Elsevier USA. All rights reserved.
PY - 2022/3/1
Y1 - 2022/3/1
N2 - The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH), which incorporates an exercise and biobehavioral coaching intervention, has the following overall goals: (a) to determine whether high-intensity interval training (HIIT) mitigates physical function impairments, fatigue, and impairments in mitochondrial bioenergetics of older people living with HIV (PLWH) to a greater extent than continuous moderate exercise (CME); and (b) to determine whether a biobehavioral coaching and mobile health text messaging intervention after HIIT or CME can promote long-term adherence to physical activity. The HEALTH study is a randomized trial of 100 older PLWH (≥50 years of age) who self-report fatigue and have a sedentary lifestyle. Enrolled participants will be randomized to 16 weeks of supervised HIIT or CME training, followed by a 12-week maintenance phase, involving a mobile health coaching intervention. Outcomes of the HEALTH study will inform the development of scalable, effective exercise recommendations tailored to the unique needs of aging PLWH.
AB - The High-Intensity Exercise Study to Attenuate Limitations and Train Habits in Older Adults With HIV (HEALTH), which incorporates an exercise and biobehavioral coaching intervention, has the following overall goals: (a) to determine whether high-intensity interval training (HIIT) mitigates physical function impairments, fatigue, and impairments in mitochondrial bioenergetics of older people living with HIV (PLWH) to a greater extent than continuous moderate exercise (CME); and (b) to determine whether a biobehavioral coaching and mobile health text messaging intervention after HIIT or CME can promote long-term adherence to physical activity. The HEALTH study is a randomized trial of 100 older PLWH (≥50 years of age) who self-report fatigue and have a sedentary lifestyle. Enrolled participants will be randomized to 16 weeks of supervised HIIT or CME training, followed by a 12-week maintenance phase, involving a mobile health coaching intervention. Outcomes of the HEALTH study will inform the development of scalable, effective exercise recommendations tailored to the unique needs of aging PLWH.
KW - HIV
KW - fatigue
KW - frailty
KW - muscle mitochondria
KW - neuromuscular manifestations
KW - physical activity
UR - http://www.scopus.com/inward/record.url?scp=85125212319&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85125212319&partnerID=8YFLogxK
U2 - 10.1097/JNC.0000000000000276
DO - 10.1097/JNC.0000000000000276
M3 - Article
C2 - 34039876
AN - SCOPUS:85125212319
SN - 1055-3290
VL - 33
SP - 178
EP - 188
JO - Journal of the Association of Nurses in AIDS Care
JF - Journal of the Association of Nurses in AIDS Care
IS - 2
ER -
