The HIV-1 coat protein gp120 regulates cxcr4-mediated signaling in neural progenitor cells

Phuong B. Tran; Dongjun Ren; Richard J. Miller

doi:10.1016/j.jneuroim.2004.11.001

The HIV-1 coat protein gp120 regulates cxcr4-mediated signaling in neural progenitor cells

Phuong B. Tran, Dongjun Ren, Richard J. Miller^*

^*Corresponding author for this work

Pharmacology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

We demonstrate that hCD4-primed gp120IIIB interacts with CXCR4 receptors expressed by postnatal mouse neural progenitor cells and elicits robust Ca ²⁺ signals. The chemokine SDF-1 acted as a chemoattractant and a mitogenic stimulus for these neural progenitor cells. Although hCD4/gp120 was not able to produce chemoattraction or increase proliferaton, it completely blocked the ability of SDF-1 to produce these effects. Thus, gp120 can act both as an agonist and de facto antagonist of CXCR4-mediated signaling in neural progenitor cells. It is possible that the ability of hCD4/gp120 to block SDF-1 signaling in neural progenitors may contribute to the neuropathological effects of HIV-1.

Original language	English (US)
Pages (from-to)	68-76
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	160
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2004.11.001
State	Published - Mar 2005

Funding

Supported by NIH grants NS043095, DA013141 and MH040165.

Keywords

Chemokines
Dementia
HIV-1
Migration
Neural stem cells

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Neurology
Clinical Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.jneuroim.2004.11.001

Cite this

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title = "The HIV-1 coat protein gp120 regulates cxcr4-mediated signaling in neural progenitor cells",

abstract = "We demonstrate that hCD4-primed gp120IIIB interacts with CXCR4 receptors expressed by postnatal mouse neural progenitor cells and elicits robust Ca 2+ signals. The chemokine SDF-1 acted as a chemoattractant and a mitogenic stimulus for these neural progenitor cells. Although hCD4/gp120 was not able to produce chemoattraction or increase proliferaton, it completely blocked the ability of SDF-1 to produce these effects. Thus, gp120 can act both as an agonist and de facto antagonist of CXCR4-mediated signaling in neural progenitor cells. It is possible that the ability of hCD4/gp120 to block SDF-1 signaling in neural progenitors may contribute to the neuropathological effects of HIV-1.",

keywords = "Chemokines, Dementia, HIV-1, Migration, Neural stem cells",

author = "Tran, {Phuong B.} and Dongjun Ren and Miller, {Richard J.}",

note = "Funding Information: Supported by NIH grants NS043095, DA013141 and MH040165. ",

year = "2005",

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doi = "10.1016/j.jneuroim.2004.11.001",

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AU - Ren, Dongjun

AU - Miller, Richard J.

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PY - 2005/3

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AB - We demonstrate that hCD4-primed gp120IIIB interacts with CXCR4 receptors expressed by postnatal mouse neural progenitor cells and elicits robust Ca 2+ signals. The chemokine SDF-1 acted as a chemoattractant and a mitogenic stimulus for these neural progenitor cells. Although hCD4/gp120 was not able to produce chemoattraction or increase proliferaton, it completely blocked the ability of SDF-1 to produce these effects. Thus, gp120 can act both as an agonist and de facto antagonist of CXCR4-mediated signaling in neural progenitor cells. It is possible that the ability of hCD4/gp120 to block SDF-1 signaling in neural progenitors may contribute to the neuropathological effects of HIV-1.

KW - Chemokines

KW - Dementia

KW - HIV-1

KW - Migration

KW - Neural stem cells

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The HIV-1 coat protein gp120 regulates cxcr4-mediated signaling in neural progenitor cells

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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