Abstract
Due to its central role in cell biology, the cytoskeleton is a key regulator of viral infection, influencing nearly every step of the viral life cycle. In this review, we will discuss the role of two key components of the cytoskeleton, namely the actin and microtubule networks in early HIV-1 infection. We will discuss key contributions to processes ranging from the attachment and entry of viral particles at the cell surface to their arrival and import into the nucleus and identify areas where further research into this complex relationship may yield new insights into HIV-1 pathogenesis.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1835-1848 |
| Number of pages | 14 |
| Journal | FEBS Journal |
| Volume | 291 |
| Issue number | 9 |
| DOIs | |
| State | Published - May 2024 |
Funding
We apologize to all colleagues whose work was not cited due to the focus of this review and working within space constraints. This work was supported by the grant (R01AI150559) from the National Institute of Health to MHN.
Keywords
- HIV-1
- actin
- cytoskeleton
- microtubules
- motors
- trafficking
- uncoating
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology
- Cell Biology
