The human cytolytic T lymphocyte response to transplantation antigens

Alan M. Krensky*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Cytolytic T lymphocytes are important effectors in the immune response to allografts, viral infections, and some tumors. Cytolytic T lymphocyte lines and clones have been generated and used to define functionally relevant effector and target cell surface molecules. The major target antigens of the human allogeneic response are the major histocompatibility complex antigens. Functionally relevant effector antigens include LFA-1, LFA-2, LFA-3, OKT4, OKT8, OKT3, and Ti, the T cell receptor. The diagnostic and therapeutic implications of T cell surface molecules are discussed.

Original languageEnglish (US)
Pages (from-to)1231-1234
Number of pages4
JournalPediatric research
Volume19
Issue number12
DOIs
StatePublished - Dec 1985

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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