@article{f822bf79f0b84a0192f7505c3f9c3d24,
title = "The human proteoform project: Defining the human proteome",
abstract = "Proteins are the primary effectors of function in biology, and thus, complete knowledge of their structure and properties is fundamental to deciphering function in basic and translational research. The chemical diversity of proteins is expressed in their many proteoforms, which result from combinations of genetic polymorphisms, RNA splice variants, and posttranslational modifications. This knowledge is foundational for the biological complexes and networks that control biology yet remains largely unknown. We propose here an ambitious initiative to define the human proteome, that is, to generate a definitive reference set of the proteoforms produced from the genome. Several examples of the power and importance of proteoform-level knowledge in disease-based research are presented along with a call for improved technologies in a two-pronged strategy to the Human Proteoform Project.",
author = "{The Consortium for Top-Down Proteomics} and Smith, {Lloyd M.} and Agar, {Jeffrey N.} and Julia Chamot-Rooke and Danis, {Paul O.} and Ying Ge and Loo, {Joseph A.} and Ljiljana Pa{\v s}a-Toli{\ae} and Tsybin, {Yury O.} and Kelleher, {Neil L.}",
note = "Funding Information: J.N.A. was supported by the ALS Association under award 508452. Y.G. was supported by the NIH under awards R01 HL096971, GM117058, and GM125085. N.L.K. was supported by the National Institute of General Medical Sciences (NIGMS) at NIH under award P41GM108569 and the NIH Common Fund under award UG3CA246635. J.A.L. was supported by the NIH under award R01GM103479 and the Department of Energy under award DE-FC02-02ER63421. L.M.S. was supported by the NIGMS under award R35GM126914. L.P.-T was supported under the Intramural program at the Environmental Molecular Sciences Laboratory (a DOE Office of Science User Facility sponsored by the Office of Biological and Environmental Research and operated under contract DE-AC05- 76RL01830) and the NIH Common Fund under award UG3CA256959. J.C.-R. and Y.O.T. were supported by the European Horizon 2020 program under award 829157, and J.C.-R. was also supported by the Institut Pasteur, the CNRS, and EPIC-XS under award 823839. We acknowledge M. W. Mullowney for assistance in generating figures. Publisher Copyright: Copyright {\textcopyright} 2021 The Authors.",
year = "2021",
month = nov,
doi = "10.1126/sciadv.abk0734",
language = "English (US)",
volume = "7",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "46",
}
