The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study

Peng Liu; Guangyu Zhou; Yi Zhang; Minghao Dong; Wei Qin; Kai Yuan; Jinbo Sun; Jixin Liu; Jimin Liang; Karen M. von Deneen; Yijun Liu; Jie Tian

doi:10.1016/j.neulet.2010.05.077

The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study

Peng Liu, Guangyu Zhou, Yi Zhang, Minghao Dong, Wei Qin, Kai Yuan, Jinbo Sun, Jixin Liu, Jimin Liang, Karen M. von Deneen, Yijun Liu, Jie Tian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Ample clinical reports and neuroimaging studies have demonstrated that the acupuncture has sustained effects after manipulation. However, most previous fMRI studies of acupuncture have paid little attention to this issue, only investigating on the manipulation effects. In the current study, we attempted to explore both acupuncture effects, which have positive influence to therapeutic efficiency, to reveal the neural mechanism of acupuncture. This paper combined the conventional general linear model (GLM) and independent component analysis (ICA) to study the topography and the temporal feature of brain activity to detect the brain responses to stimulation at ST36 (Zusanli) and a sham acupoint. The results showed that the manipulation-related effects and the sustained acupuncture effects separately induced statistically significant increases/decreases in the cortical-subcortical areas, including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), supplementary motor area (SMA) primary/secondary somatosensory cortex (SI/SII), occipital cortices and midbrain. Our findings suggested that the analgesia effects of ST36 integrated sophisticated physiological and psychological procedures. In addition, our results have shed light on methodology in acupuncture research.

Original language	English (US)
Pages (from-to)	267-271
Number of pages	5
Journal	Neuroscience Letters
Volume	479
Issue number	3
DOIs	https://doi.org/10.1016/j.neulet.2010.05.077
State	Published - Aug 2010
Externally published	Yes

Funding

This study is supported by Changjiang Scholars and Innovative Research Team in University (PCSIRT) under Grant No. IRT0645 , the Chair Professors of Cheung Kong Scholars Program of Ministry of Education of China, CAS Hundred Talents Program, the Joint Research Fund for Overseas Chinese Young Scholars under Grant No. 30528027 , the National Natural Science Foundation of China under Grant Nos. 30970774 , 60901064 , 30873462 , 30870685 , 30672690 , 30600151 , 60532050 , 60621001 , the knowledge innovation program of the Chinese academy of sciences under Grant No. KGCX2-YW-129 , the Project for the National Key Basic Research and Development Program (973) under Grant No. 2006CB705700 , and 863 program under Grant No. 2008AA01Z411 , Basic Science Research Fund in Xidian University.

Keywords

Acupuncture
FMRI
GLM
ICA

ASJC Scopus subject areas

General Neuroscience

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10.1016/j.neulet.2010.05.077

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@article{48db1ce81e3b4d17a70768a0d7d2a327,

title = "The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study",

abstract = "Ample clinical reports and neuroimaging studies have demonstrated that the acupuncture has sustained effects after manipulation. However, most previous fMRI studies of acupuncture have paid little attention to this issue, only investigating on the manipulation effects. In the current study, we attempted to explore both acupuncture effects, which have positive influence to therapeutic efficiency, to reveal the neural mechanism of acupuncture. This paper combined the conventional general linear model (GLM) and independent component analysis (ICA) to study the topography and the temporal feature of brain activity to detect the brain responses to stimulation at ST36 (Zusanli) and a sham acupoint. The results showed that the manipulation-related effects and the sustained acupuncture effects separately induced statistically significant increases/decreases in the cortical-subcortical areas, including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), supplementary motor area (SMA) primary/secondary somatosensory cortex (SI/SII), occipital cortices and midbrain. Our findings suggested that the analgesia effects of ST36 integrated sophisticated physiological and psychological procedures. In addition, our results have shed light on methodology in acupuncture research.",

keywords = "Acupuncture, FMRI, GLM, ICA",

author = "Peng Liu and Guangyu Zhou and Yi Zhang and Minghao Dong and Wei Qin and Kai Yuan and Jinbo Sun and Jixin Liu and Jimin Liang and {von Deneen}, {Karen M.} and Yijun Liu and Jie Tian",

note = "Funding Information: This study is supported by Changjiang Scholars and Innovative Research Team in University (PCSIRT) under Grant No. IRT0645 , the Chair Professors of Cheung Kong Scholars Program of Ministry of Education of China, CAS Hundred Talents Program, the Joint Research Fund for Overseas Chinese Young Scholars under Grant No. 30528027 , the National Natural Science Foundation of China under Grant Nos. 30970774 , 60901064 , 30873462 , 30870685 , 30672690 , 30600151 , 60532050 , 60621001 , the knowledge innovation program of the Chinese academy of sciences under Grant No. KGCX2-YW-129 , the Project for the National Key Basic Research and Development Program (973) under Grant No. 2006CB705700 , and 863 program under Grant No. 2008AA01Z411 , Basic Science Research Fund in Xidian University.",

year = "2010",

month = aug,

doi = "10.1016/j.neulet.2010.05.077",

language = "English (US)",

volume = "479",

pages = "267--271",

journal = "Neuroscience Letters",

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T1 - The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36

T2 - An fMRI study

AU - Liu, Peng

AU - Zhou, Guangyu

AU - Zhang, Yi

AU - Dong, Minghao

AU - Qin, Wei

AU - Yuan, Kai

AU - Sun, Jinbo

AU - Liu, Jixin

AU - Liang, Jimin

AU - von Deneen, Karen M.

AU - Liu, Yijun

AU - Tian, Jie

N1 - Funding Information: This study is supported by Changjiang Scholars and Innovative Research Team in University (PCSIRT) under Grant No. IRT0645 , the Chair Professors of Cheung Kong Scholars Program of Ministry of Education of China, CAS Hundred Talents Program, the Joint Research Fund for Overseas Chinese Young Scholars under Grant No. 30528027 , the National Natural Science Foundation of China under Grant Nos. 30970774 , 60901064 , 30873462 , 30870685 , 30672690 , 30600151 , 60532050 , 60621001 , the knowledge innovation program of the Chinese academy of sciences under Grant No. KGCX2-YW-129 , the Project for the National Key Basic Research and Development Program (973) under Grant No. 2006CB705700 , and 863 program under Grant No. 2008AA01Z411 , Basic Science Research Fund in Xidian University.

PY - 2010/8

Y1 - 2010/8

N2 - Ample clinical reports and neuroimaging studies have demonstrated that the acupuncture has sustained effects after manipulation. However, most previous fMRI studies of acupuncture have paid little attention to this issue, only investigating on the manipulation effects. In the current study, we attempted to explore both acupuncture effects, which have positive influence to therapeutic efficiency, to reveal the neural mechanism of acupuncture. This paper combined the conventional general linear model (GLM) and independent component analysis (ICA) to study the topography and the temporal feature of brain activity to detect the brain responses to stimulation at ST36 (Zusanli) and a sham acupoint. The results showed that the manipulation-related effects and the sustained acupuncture effects separately induced statistically significant increases/decreases in the cortical-subcortical areas, including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), supplementary motor area (SMA) primary/secondary somatosensory cortex (SI/SII), occipital cortices and midbrain. Our findings suggested that the analgesia effects of ST36 integrated sophisticated physiological and psychological procedures. In addition, our results have shed light on methodology in acupuncture research.

AB - Ample clinical reports and neuroimaging studies have demonstrated that the acupuncture has sustained effects after manipulation. However, most previous fMRI studies of acupuncture have paid little attention to this issue, only investigating on the manipulation effects. In the current study, we attempted to explore both acupuncture effects, which have positive influence to therapeutic efficiency, to reveal the neural mechanism of acupuncture. This paper combined the conventional general linear model (GLM) and independent component analysis (ICA) to study the topography and the temporal feature of brain activity to detect the brain responses to stimulation at ST36 (Zusanli) and a sham acupoint. The results showed that the manipulation-related effects and the sustained acupuncture effects separately induced statistically significant increases/decreases in the cortical-subcortical areas, including the anterior cingulate cortex (ACC), ventrolateral prefrontal cortex (VLPFC), supplementary motor area (SMA) primary/secondary somatosensory cortex (SI/SII), occipital cortices and midbrain. Our findings suggested that the analgesia effects of ST36 integrated sophisticated physiological and psychological procedures. In addition, our results have shed light on methodology in acupuncture research.

KW - Acupuncture

KW - FMRI

KW - GLM

KW - ICA

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JO - Neuroscience Letters

JF - Neuroscience Letters

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ER -

The hybrid GLM-ICA investigation on the neural mechanism of acupoint ST36: An fMRI study

Abstract

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Keywords

ASJC Scopus subject areas

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