The hygiene hypothesis revisited: Does exposure to infectious agents protect us from allergy?

Anna Fishbein, Ramsay L Fuleihan*

*Corresponding author for this work

Research output: Contribution to journalReview article

40 Citations (Scopus)

Abstract

Purpose of review: The increase in incidence and prevalence of allergic disease remains a mystery and cannot be explained solely by genetic factors. The hygiene hypothesis provides the strongest epidemiological explanation for the rise in allergic disease. This review evaluates the recent epidemiological and mechanistic research in the role of infectious agents in the pathogenesis of or protection from allergic disease. Recent findings: Recent literature has extended the epidemiological findings of the protective effect of being born and reared in a farm environment and associates an increased diversity of organisms in house-dust samples with protection from allergic disease. Furthermore, human and animal studies provide increasing evidence for the role of both the innate and adaptive immune systems, including regulatory cells, as mediators of this protective effect. Summary: There is evidence that exposure to some infectious organisms can protect from atopy, whereas other infections appear to promote allergic diseases. The timing of exposure to infection and the properties of the infectious agent, in addition to the genetic susceptibility of the host, play an important role in the future development of allergic disease.

Original languageEnglish (US)
Pages (from-to)98-102
Number of pages5
JournalCurrent opinion in pediatrics
Volume24
Issue number1
DOIs
StatePublished - Feb 1 2012

Fingerprint

Hygiene Hypothesis
Hypersensitivity
Genetic Predisposition to Disease
Infection
Dust
Immune System
Incidence
Research

Keywords

  • allergy
  • farm-rearing
  • hygiene hypothesis
  • infection
  • regulatory cells

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

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The hygiene hypothesis revisited : Does exposure to infectious agents protect us from allergy? / Fishbein, Anna; Fuleihan, Ramsay L.

In: Current opinion in pediatrics, Vol. 24, No. 1, 01.02.2012, p. 98-102.

Research output: Contribution to journalReview article

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N2 - Purpose of review: The increase in incidence and prevalence of allergic disease remains a mystery and cannot be explained solely by genetic factors. The hygiene hypothesis provides the strongest epidemiological explanation for the rise in allergic disease. This review evaluates the recent epidemiological and mechanistic research in the role of infectious agents in the pathogenesis of or protection from allergic disease. Recent findings: Recent literature has extended the epidemiological findings of the protective effect of being born and reared in a farm environment and associates an increased diversity of organisms in house-dust samples with protection from allergic disease. Furthermore, human and animal studies provide increasing evidence for the role of both the innate and adaptive immune systems, including regulatory cells, as mediators of this protective effect. Summary: There is evidence that exposure to some infectious organisms can protect from atopy, whereas other infections appear to promote allergic diseases. The timing of exposure to infection and the properties of the infectious agent, in addition to the genetic susceptibility of the host, play an important role in the future development of allergic disease.

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