The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: paving the way for new diagnostic criteria for gestational diabetes mellitus

Donald R. Coustan*, Lynn P. Lowe, Boyd E. Metzger, Alan R. Dyer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

210 Scopus citations

Abstract

The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study was performed in response to the need for internationally agreed upon diagnostic criteria for gestational diabetes, based upon their predictive value for adverse pregnancy outcome. Increases in each of the 3 values on the 75-g, 2-hour oral glucose tolerance test are associated with graded increases in the likelihood of pregnancy outcomes such as large for gestational age, cesarean section, fetal insulin levels, and neonatal fat content. Based upon an iterative process of decision making, a task force of the International Association of Diabetes and Pregnancy Study Groups recommends that the diagnosis of gestational diabetes be made when any of the following 3 75-g, 2-hour oral glucose tolerance test thresholds are met or exceeded: fasting 92 mg/dL, 1-hour 180 mg/dL, or 2 hours 153 mg/dL. Various authoritative bodies around the world are expected to deliberate the adoption of these criteria.

Original languageEnglish (US)
Pages (from-to)654.e1-654.e6
JournalAmerican journal of obstetrics and gynecology
Volume202
Issue number6
DOIs
StatePublished - Jun 2010

Keywords

  • Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
  • diagnostic oral glucose tolerance test criteria
  • gestational diabetes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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