TY - JOUR
T1 - The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
T2 - paving the way for new diagnostic criteria for gestational diabetes mellitus
AU - Coustan, Donald R.
AU - Lowe, Lynn P.
AU - Metzger, Boyd E.
AU - Dyer, Alan R.
N1 - Funding Information:
The HAPO study was supported by grants from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Institute of Diabetes and Digestive and Kidney Diseases ( R01-HD34242 and R01-HD34243 ), the National Center for Research Resources ( M01-RR00048 and M01-RR00080 ), and the American Diabetes Association .
PY - 2010/6
Y1 - 2010/6
N2 - The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study was performed in response to the need for internationally agreed upon diagnostic criteria for gestational diabetes, based upon their predictive value for adverse pregnancy outcome. Increases in each of the 3 values on the 75-g, 2-hour oral glucose tolerance test are associated with graded increases in the likelihood of pregnancy outcomes such as large for gestational age, cesarean section, fetal insulin levels, and neonatal fat content. Based upon an iterative process of decision making, a task force of the International Association of Diabetes and Pregnancy Study Groups recommends that the diagnosis of gestational diabetes be made when any of the following 3 75-g, 2-hour oral glucose tolerance test thresholds are met or exceeded: fasting 92 mg/dL, 1-hour 180 mg/dL, or 2 hours 153 mg/dL. Various authoritative bodies around the world are expected to deliberate the adoption of these criteria.
AB - The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study was performed in response to the need for internationally agreed upon diagnostic criteria for gestational diabetes, based upon their predictive value for adverse pregnancy outcome. Increases in each of the 3 values on the 75-g, 2-hour oral glucose tolerance test are associated with graded increases in the likelihood of pregnancy outcomes such as large for gestational age, cesarean section, fetal insulin levels, and neonatal fat content. Based upon an iterative process of decision making, a task force of the International Association of Diabetes and Pregnancy Study Groups recommends that the diagnosis of gestational diabetes be made when any of the following 3 75-g, 2-hour oral glucose tolerance test thresholds are met or exceeded: fasting 92 mg/dL, 1-hour 180 mg/dL, or 2 hours 153 mg/dL. Various authoritative bodies around the world are expected to deliberate the adoption of these criteria.
KW - Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
KW - diagnostic oral glucose tolerance test criteria
KW - gestational diabetes
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U2 - 10.1016/j.ajog.2010.04.006
DO - 10.1016/j.ajog.2010.04.006
M3 - Article
C2 - 20510967
AN - SCOPUS:77952863068
VL - 202
SP - 654.e1-654.e6
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 6
ER -
