The hyperviscosity syndrome in rheumatoid arthritis due to intermediate complexes formed by self‐association of IgG‐rheumatoid factors

Richard M. Pope, Mart Mannik*, Bruce C. Gilliland, David C. Teller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

Three patients with rheumatoid arthritis and abundant circulating intermediate complexes were studied. Two of these patients presented with the hyperviscosity syndrome. All 3 patients had markedly elevated plasma and blood viscosity, and the intermediate complexes were thought to be responsible for the increased viscosity. Studies on the isolated intermediate complexes revealed that they were formed by self‐association of IgG‐rheumatoid factors.

Original languageEnglish (US)
Pages (from-to)97-106
Number of pages10
JournalArthritis & Rheumatism
Volume18
Issue number2
DOIs
StatePublished - 1975

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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