The identification of novel therapeutic targets for the treatment of malignant brain tumors

Roger A. Kroes, Aaron Jastrow, Michael G. McLone, Hirotaka Yamamoto, Patricia Colley, Donna S. Kersey, Voon Wee Yong, Edward Mkrdichian, Leonard Cerullo, Jan Leestma, Joseph R. Moskal*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

87 Scopus citations

Abstract

A two-step strategy was developed consisting of differential display reverse transcriptase polymerase chain reaction (DDRT-PCR) with cultured normal human fetal astrocytes and U-373MG glioma cells followed by reverse Northern analysis of normal brain and primary tumor tissues. hu-dek, α-NAC, ribosomal proteins L7a and L35a, and five novel genes were identified. Since none of these genes has been previously shown to be associated with malignant brain tumor formation, this approach may be useful to identify novel targets for the diagnosis and treatment of brain tumors. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish (US)
Pages (from-to)191-198
Number of pages8
JournalCancer Letters
Volume156
Issue number2
DOIs
StatePublished - Aug 11 2000

Keywords

  • Differential display
  • Expression screen
  • Glioma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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