The IL-4 gene maps to chromosome 11, near the gene encoding IL-3

P. D'Eustachio, M. Brown, C. Watson, W. E. Paul

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

IL-4/B cell stimulatory factor 1 (IL-4) is a potent mediator of the growth and differentiation of cells of most hemopoietic lineages. IL-4 is one of a number of lymphokines produced by T cells after activation with Ag or mitogen. In order to map the chromosomal location of the IL-4 gene, Chinese hamster-mouse somatic cell hybrids were used in Southern blot analyses with an IL-4 cDNA probe. These results suggested that the IL-4 gene was located on chromosome 11. In contrast, the gene encoding IL-2 was localized to either chromosome 1 or 3. The identification of a strain-specific Bgl II restriction enzyme polymorphism in the IL-4 gene was used to map the IL-4 gene to a position on mouse chromosome 11 within 1 centimorgan of the gene encoding IL-3.

Original languageEnglish (US)
Pages (from-to)3067-3071
Number of pages5
JournalJournal of Immunology
Volume141
Issue number9
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Immunology

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