The immunobiology of nephritis

E. G. Neilson, S. M. Phillips

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


This review has explored modern concepts of immunobiology as they pertain to nephritis. An enlightened understanding of renal disease can only come through a more sophisticated immunologic approach to the detrimental host response. Efforts must also be directed towards the construction of appropriate and detailed mechanistic analogues of human disease. Investigational endeavors into the mechanisms of nephritis have been restricted and confined, for the most part, to those aspects of the effector pathway which occur late in the expression of disease. While this emphasis has been constructive and useful, it also has been inadequate. The challenge of future efforts will be to illuminate the role of host regulatory systems which create and propel immune mechanisms towards one of several limited modes of immuno-inflammatory pathologic expression. An understanding of these phenomena is awaited with much anticipation and with good reason. Manipulations to diminish host morbidity will become increasingly feasible as the interrelationships coordinating the immune response become more obvious. The concept of selective immunotherapy is coming of age and is the forerunner of sensible, future therapeutic interventions and ultimate immunoprophylaxis.

Original languageEnglish (US)
Pages (from-to)167-249
Number of pages83
JournalProgress in Allergy
Volumeno. 27
StatePublished - 1980
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy


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