The immunological identity of tumor: Self implications

Jason Michael Miska; Priyadharshini Devarajan; Zhibin Chen

doi:10.4161/onco.23794

The immunological identity of tumor: Self implications

Jason Michael Miska, Priyadharshini Devarajan, Zhibin Chen^*

^*Corresponding author for this work

Neurological Surgery

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.

Original language	English (US)
Article number	e23794
Journal	OncoImmunology
Volume	2
Issue number	4
DOIs	https://doi.org/10.4161/onco.23794
State	Published - Apr 2013

Keywords

Altered self
Autoimmunity
Cancer
Immunoprivileged self
Regulatory T cell (Treg)

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.4161/onco.23794

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AU - Devarajan, Priyadharshini

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AB - By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.

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KW - Cancer

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The immunological identity of tumor: Self implications

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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