The immunological identity of tumor: Self implications

Jason Michael Miska, Priyadharshini Devarajan, Zhibin Chen*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations


By means of well-characterized autoimmunity models, we comparatively probed the "selfness" of malignant cells and their normal counterparts. We found that tumors activate self-tolerance mechanisms much more efficiently than normal tissues, reflecting a status of immunoprivileged "self." Our findings indicate that potent autoimmune responses can eradicate established malignancies, yet the collateral destruction of healthy tissues may prove difficult to circumvent.

Original languageEnglish (US)
Article numbere23794
Issue number4
StatePublished - Apr 1 2013


  • Altered self
  • Autoimmunity
  • Cancer
  • Immunoprivileged self
  • Regulatory T cell (Treg)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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