The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

Stephen D Miller*, William J. Karpus

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

166 Scopus citations


A variety of experimental approaches are currently being evaluated for controlling CD4+ T helper 1 (Th1)-mediated autoimmune pathology. Here, Stephen Miller and William Karpus compare and contrast the efficacies of various antigen-specific regulatory strategies. Particular emphasis is placed on the mechanisms of peripheral immune tolerance and how this may be used in the treatment and analysis of the pathologic T-cell repertoire in autoimmune and virus-induced demyelinating diseases.

Original languageEnglish (US)
Pages (from-to)356-361
Number of pages6
JournalTrends in Immunology
Issue number8
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Immunology


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