The immunopathogenesis of a viral model of multiple sclerosis: Theiler's virus induced demyelination.

M. C. Dal Canto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Most studies suggest that the pathogenesis of Multiple Sclerosis (MS) is based on immune mechanisms of myelin injury. In addition, a viral infection, possibly established in the first few years of the patient's life, may be crucial in setting the stage for such immune mediated injury when acting on the appropriate genetic background. Of the several models of virus-induced demyelination described in the last two decades, Theiler's murine encephalomyelitis virus (TMEV) infection has emerged as one of the best models for MS.

Original languageEnglish (US)
Pages (from-to)17-22
Number of pages6
JournalItalian journal of neurological sciences
Volume13
Issue number9 Suppl 14
StatePublished - Dec 1992

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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