The impact and implications of neuropsychiatric systemic lupus erythematosus in adolescents

Marisa S Klein-Gitelman*, Hermine I. Brunner

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Citations (Scopus)

Abstract

Signs and symptoms of neuropsychiatric systemic lupus erythematosus (NPSLE), as defined by the American College of Rheumatology case definitions, occur commonly in adolescents with lupus. Thought and mood disorders are more difficult to identify than specific central or peripheral nervous system injuries. Furthermore, thought and mood disorders must be differentiated from other causes, including traumatic, metabolic, endocrinologic, toxic, and infectious etiologies. It is also important to recognize that primary mood and thought disorders can present in adolescence. The effects of chronic disease during adolescent development can also trigger alterations in mood and cognitive function. This article reviews proposed etiologies of injury, diagnosis, and differential diagnosis of NPSLE. At this time, no specific test identifies NPSLE as the cause of mood and cognitive changes; however, current efforts to standardize evaluation of cognitive function and develop imaging techniques that identify anatomic brain changes will improve the practice of rheumatology.

Original languageEnglish (US)
Pages (from-to)212-217
Number of pages6
JournalCurrent Rheumatology Reports
Volume11
Issue number3
DOIs
StatePublished - Jul 1 2009

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Central Nervous System Lupus Vasculitis
Mood Disorders
Cognition
Nervous System Trauma
Adolescent Development
Poisons
Peripheral Nervous System
Rheumatology
Signs and Symptoms
Differential Diagnosis
Chronic Disease
Central Nervous System
Wounds and Injuries
Brain

ASJC Scopus subject areas

  • Rheumatology

Cite this

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title = "The impact and implications of neuropsychiatric systemic lupus erythematosus in adolescents",
abstract = "Signs and symptoms of neuropsychiatric systemic lupus erythematosus (NPSLE), as defined by the American College of Rheumatology case definitions, occur commonly in adolescents with lupus. Thought and mood disorders are more difficult to identify than specific central or peripheral nervous system injuries. Furthermore, thought and mood disorders must be differentiated from other causes, including traumatic, metabolic, endocrinologic, toxic, and infectious etiologies. It is also important to recognize that primary mood and thought disorders can present in adolescence. The effects of chronic disease during adolescent development can also trigger alterations in mood and cognitive function. This article reviews proposed etiologies of injury, diagnosis, and differential diagnosis of NPSLE. At this time, no specific test identifies NPSLE as the cause of mood and cognitive changes; however, current efforts to standardize evaluation of cognitive function and develop imaging techniques that identify anatomic brain changes will improve the practice of rheumatology.",
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The impact and implications of neuropsychiatric systemic lupus erythematosus in adolescents. / Klein-Gitelman, Marisa S; Brunner, Hermine I.

In: Current Rheumatology Reports, Vol. 11, No. 3, 01.07.2009, p. 212-217.

Research output: Contribution to journalReview article

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N2 - Signs and symptoms of neuropsychiatric systemic lupus erythematosus (NPSLE), as defined by the American College of Rheumatology case definitions, occur commonly in adolescents with lupus. Thought and mood disorders are more difficult to identify than specific central or peripheral nervous system injuries. Furthermore, thought and mood disorders must be differentiated from other causes, including traumatic, metabolic, endocrinologic, toxic, and infectious etiologies. It is also important to recognize that primary mood and thought disorders can present in adolescence. The effects of chronic disease during adolescent development can also trigger alterations in mood and cognitive function. This article reviews proposed etiologies of injury, diagnosis, and differential diagnosis of NPSLE. At this time, no specific test identifies NPSLE as the cause of mood and cognitive changes; however, current efforts to standardize evaluation of cognitive function and develop imaging techniques that identify anatomic brain changes will improve the practice of rheumatology.

AB - Signs and symptoms of neuropsychiatric systemic lupus erythematosus (NPSLE), as defined by the American College of Rheumatology case definitions, occur commonly in adolescents with lupus. Thought and mood disorders are more difficult to identify than specific central or peripheral nervous system injuries. Furthermore, thought and mood disorders must be differentiated from other causes, including traumatic, metabolic, endocrinologic, toxic, and infectious etiologies. It is also important to recognize that primary mood and thought disorders can present in adolescence. The effects of chronic disease during adolescent development can also trigger alterations in mood and cognitive function. This article reviews proposed etiologies of injury, diagnosis, and differential diagnosis of NPSLE. At this time, no specific test identifies NPSLE as the cause of mood and cognitive changes; however, current efforts to standardize evaluation of cognitive function and develop imaging techniques that identify anatomic brain changes will improve the practice of rheumatology.

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