The impact of bioactive molecules to stimulate tooth repair and regeneration as part of restorative dentistry

Michel Goldberg*, Sally Lacerda-Pinheiro, Nadege Jegat, Ngampis Six, Dominique Septier, Fabienne Priam, Mireille Bonnefoix, Kevin Tompkins, Hélène Chardin, Pamela Denbesten, Arthur Veis, Anne Poliard

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

55 Scopus citations

Abstract

After implantation in the exposed pulp, some molecules of the dentin extracellular matrix induce the formation of a reparative dentinal bridge in the coronal pulp. In some cases, total occlusion of the root canal also is observed. This is the case for bone sialoprotein, bone morphogenetic protein-7, Dentonin (a fragment from matrix extracellular phosphoglycoprotein), and two small amelogenin gene splice products (A+4 and A-4). Cells implicated in the reparative process are recruited, proliferate, and differentiate into osteoblast-like and odontoblast-like cells. The same results may be obtained by direct implantation of odontoblast progenitor cell into the pulp.

Original languageEnglish (US)
Pages (from-to)277-298
Number of pages22
JournalDental clinics of North America
Volume50
Issue number2
DOIs
StatePublished - Apr 1 2006

ASJC Scopus subject areas

  • Dentistry(all)

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