The impact of biomarkers of acute kidney injury on individual patient care

Jay L. Koyner*, Alexander Zarbock, Rajit K. Basu, Claudio Ronco

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Acute kidney injury (AKI) remains a common clinical syndrome associated with increased morbidity and mortality. In the last several years there have been several advances in the identification of patients at increased risk for AKI through the use of traditional and newer functional and damage biomarkers of AKI. This article will specifically focus on the impact of biomarkers of AKI on individual patient care, focusing predominantly on the markers with the most expansive breadth of study in patients and reported literature evidence. Several studies have demonstrated that close monitoring of widely available biomarkers such as serum creatinine and urine output is strongly associated with improved patient outcomes. An integrated approach to these biomarkers used in context with patient risk factors (identifiable using electronic health record monitoring) and with tests of renal reserve may guide implementation and targeting of care bundles to optimize patient care. Besides traditional functional markers, biochemical injury biomarkers have been increasingly utilized in clinical trials both as a measure of kidney injury as well as a trigger to initiate other treatment options (e.g. care bundles and novel therapies). As the novel measures are becoming globally available, the clinical implementation of hospital-based real-time biomarker measurements involves a multidisciplinary approach. This literature review discusses the data evidence supporting both the strengths and limitations in the clinical implementation of biomarkers based on the authors’ collective clinical experiences and opinions.

Original languageEnglish (US)
Pages (from-to)1295-1305
Number of pages11
JournalNephrology Dialysis Transplantation
Volume35
Issue number8
DOIs
StatePublished - Aug 1 2020
Externally publishedYes

Keywords

  • Acute kidney injury
  • Biomarker
  • Patient outcome
  • Renal replacement therapy

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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