The impact of campath 1H induction in adult liver allotransplantation

P. Tryphonopoulos; J. R. Madariaga; T. Kato; S. Nishida; D. M. Levi; J. Moon; G. Selvaggi; W. De Faria; A. Regev; P. Bejarano; A. Khaled; K. Safdar; V. Esquenazi; D. Weppler; H. Yoshida; P. Ruiz; J. Miller; A. G. Tzakis

doi:10.1016/j.transproceed.2004.12.157

The impact of campath 1H induction in adult liver allotransplantation

P. Tryphonopoulos, J. R. Madariaga, T. Kato, S. Nishida, D. M. Levi, J. Moon, G. Selvaggi, W. De Faria, A. Regev, P. Bejarano, A. Khaled, K. Safdar, V. Esquenazi, D. Weppler, H. Yoshida, P. Ruiz, J. Miller, A. G. Tzakis^*

^*Corresponding author for this work

Surgery, Transplant Surgery Division

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Background. We report our experience with Campath 1H in adult liver allotransplantation. Methods. Between December 2001 and February 2004, 77 patients underwent liver transplantation using Campath 1H induction and low-dose maintenance tacrolimus immunosuppression. The control group consisted of 50 patients with similar baseline characteristics and the same eligibility criteria, transplanted under our standard Tacrolimus/steroids regimen. Hepatitis C patients were excluded from the study. Results. Patient and graft survival were similar for both groups. The incidence of rejection was significantly lower in the Campath vs the control group (51% vs 65% at 12 months, P = .009). Tacrolimus trough levels and conversion from Tacrolimus or the addition of other immunosuppressive drugs due to nephrotoxicity were also significantly lower in the Campath 1H group. Conclusion. Campath 1H induction with low-dose Tacrolimus maintenance immunosuppression is an effective regimen in reducing acute rejection in adult liver transplantation, while maintaining lower tacrolimus levels and less nephrotoxicity than our conventional immunosuppressive regimen.

Original language	English (US)
Pages (from-to)	1203-1204
Number of pages	2
Journal	Transplantation proceedings
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.transproceed.2004.12.157
State	Published - Mar 2005

ASJC Scopus subject areas

Surgery
Transplantation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.transproceed.2004.12.157

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Tryphonopoulos, P., Madariaga, J. R., Kato, T., Nishida, S., Levi, D. M., Moon, J., Selvaggi, G., De Faria, W., Regev, A., Bejarano, P., Khaled, A., Safdar, K., Esquenazi, V., Weppler, D., Yoshida, H., Ruiz, P., Miller, J., & Tzakis, A. G. (2005). The impact of campath 1H induction in adult liver allotransplantation. Transplantation proceedings, 37(2), 1203-1204. https://doi.org/10.1016/j.transproceed.2004.12.157

@article{1ef3f66128764d59a043fa14d0baf63e,

title = "The impact of campath 1H induction in adult liver allotransplantation",

abstract = "Background. We report our experience with Campath 1H in adult liver allotransplantation. Methods. Between December 2001 and February 2004, 77 patients underwent liver transplantation using Campath 1H induction and low-dose maintenance tacrolimus immunosuppression. The control group consisted of 50 patients with similar baseline characteristics and the same eligibility criteria, transplanted under our standard Tacrolimus/steroids regimen. Hepatitis C patients were excluded from the study. Results. Patient and graft survival were similar for both groups. The incidence of rejection was significantly lower in the Campath vs the control group (51% vs 65% at 12 months, P = .009). Tacrolimus trough levels and conversion from Tacrolimus or the addition of other immunosuppressive drugs due to nephrotoxicity were also significantly lower in the Campath 1H group. Conclusion. Campath 1H induction with low-dose Tacrolimus maintenance immunosuppression is an effective regimen in reducing acute rejection in adult liver transplantation, while maintaining lower tacrolimus levels and less nephrotoxicity than our conventional immunosuppressive regimen.",

author = "P. Tryphonopoulos and Madariaga, {J. R.} and T. Kato and S. Nishida and Levi, {D. M.} and J. Moon and G. Selvaggi and {De Faria}, W. and A. Regev and P. Bejarano and A. Khaled and K. Safdar and V. Esquenazi and D. Weppler and H. Yoshida and P. Ruiz and J. Miller and Tzakis, {A. G.}",

year = "2005",

month = mar,

doi = "10.1016/j.transproceed.2004.12.157",

language = "English (US)",

volume = "37",

pages = "1203--1204",

journal = "Transplantation proceedings",

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number = "2",

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Tryphonopoulos, P, Madariaga, JR, Kato, T, Nishida, S, Levi, DM, Moon, J, Selvaggi, G, De Faria, W, Regev, A, Bejarano, P, Khaled, A, Safdar, K, Esquenazi, V, Weppler, D, Yoshida, H, Ruiz, P, Miller, J & Tzakis, AG 2005, 'The impact of campath 1H induction in adult liver allotransplantation', Transplantation proceedings, vol. 37, no. 2, pp. 1203-1204. https://doi.org/10.1016/j.transproceed.2004.12.157

TY - JOUR

T1 - The impact of campath 1H induction in adult liver allotransplantation

AU - Tryphonopoulos, P.

AU - Madariaga, J. R.

AU - Kato, T.

AU - Nishida, S.

AU - Levi, D. M.

AU - Moon, J.

AU - Selvaggi, G.

AU - De Faria, W.

AU - Regev, A.

AU - Bejarano, P.

AU - Khaled, A.

AU - Safdar, K.

AU - Esquenazi, V.

AU - Weppler, D.

AU - Yoshida, H.

AU - Ruiz, P.

AU - Miller, J.

AU - Tzakis, A. G.

PY - 2005/3

Y1 - 2005/3

N2 - Background. We report our experience with Campath 1H in adult liver allotransplantation. Methods. Between December 2001 and February 2004, 77 patients underwent liver transplantation using Campath 1H induction and low-dose maintenance tacrolimus immunosuppression. The control group consisted of 50 patients with similar baseline characteristics and the same eligibility criteria, transplanted under our standard Tacrolimus/steroids regimen. Hepatitis C patients were excluded from the study. Results. Patient and graft survival were similar for both groups. The incidence of rejection was significantly lower in the Campath vs the control group (51% vs 65% at 12 months, P = .009). Tacrolimus trough levels and conversion from Tacrolimus or the addition of other immunosuppressive drugs due to nephrotoxicity were also significantly lower in the Campath 1H group. Conclusion. Campath 1H induction with low-dose Tacrolimus maintenance immunosuppression is an effective regimen in reducing acute rejection in adult liver transplantation, while maintaining lower tacrolimus levels and less nephrotoxicity than our conventional immunosuppressive regimen.

AB - Background. We report our experience with Campath 1H in adult liver allotransplantation. Methods. Between December 2001 and February 2004, 77 patients underwent liver transplantation using Campath 1H induction and low-dose maintenance tacrolimus immunosuppression. The control group consisted of 50 patients with similar baseline characteristics and the same eligibility criteria, transplanted under our standard Tacrolimus/steroids regimen. Hepatitis C patients were excluded from the study. Results. Patient and graft survival were similar for both groups. The incidence of rejection was significantly lower in the Campath vs the control group (51% vs 65% at 12 months, P = .009). Tacrolimus trough levels and conversion from Tacrolimus or the addition of other immunosuppressive drugs due to nephrotoxicity were also significantly lower in the Campath 1H group. Conclusion. Campath 1H induction with low-dose Tacrolimus maintenance immunosuppression is an effective regimen in reducing acute rejection in adult liver transplantation, while maintaining lower tacrolimus levels and less nephrotoxicity than our conventional immunosuppressive regimen.

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The impact of campath 1H induction in adult liver allotransplantation

Abstract

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