The impact of clinical and sociodemographic features on quality of life in patients with early stage cancers using the Functional Assessment of Cancer Therapy-General assessment tool

Marko Popovic, Nicholas Lao, Liang Zeng, Liying Zhang, David Cella, Jennifer L. Beaumont, Ronald Chow, Nicholas Chiu, Leonard Chiu, Henry Lam, Michael Poon, Edward Chow*

*Corresponding author for this work

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Purpose: This study aims to compare the Functional Assessment of Cancer Therapy-General (FACT-G) quality of life (QOL) scores of patient groups with varying clinical and sociodemographic features in the early stage cancer population. Methods: A literature search was conducted on both the Embase and OvidSP platforms. Weighted analysis of variance (ANOVA) was performed for binary predictors and weighted linear regression analysis was conducted for continuous predictors. Results: Six binary features predicted at least one domain of QOL: primary cancer site (homogeneous versus heterogeneous), total per capita healthcare expenditures, mean age, previous chemotherapy, radiotherapy, and previous hormonal therapy. Two continuous factors had predictive value with respect to QOL: completion of postsecondary education and marital status. Conclusion: Although there are limitations of the current study, similar correlations to our own have been previously described between QOL and healthcare expenditures, mean age and education. Currently, the literature conflicts in its analysis of previous radiotherapy and chemotherapy as predictors of QOL. No published evidence exists describing the presently found relationships in primary cancer site, marital status and hormonal therapy. Future work may focus on determining cause and effect relationships between these predictors and QOL.

Original languageEnglish (US)
Pages (from-to)2267-2277
Number of pages11
JournalSupportive Care in Cancer
Volume21
Issue number8
DOIs
StatePublished - Aug 1 2013

Keywords

  • Early stage cancer
  • Functional Assessment of Cancer Therapy-General
  • Quality of life
  • Treatment

ASJC Scopus subject areas

  • Oncology

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