The impact of infection control upon hospital-acquired influenza and respiratory syncytial virus

Kathryn M. Weedon; Angela H. Rupp; Annie C. Heffron; Sinead Forkan Kelly; Xiaotian Zheng; Stanford T. Shulman; Peggy Gutman; Deli Wang; Ying Zhou; Gary A. Noskin; Evan J. Anderson

doi:10.3109/00365548.2012.726738

The impact of infection control upon hospital-acquired influenza and respiratory syncytial virus

Kathryn M. Weedon, Angela H. Rupp, Annie C. Heffron, Sinead Forkan Kelly, Xiaotian Zheng, Stanford T. Shulman, Peggy Gutman, Deli Wang, Ying Zhou, Gary A. Noskin, Evan J. Anderson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Background: Respiratory syncytial virus (RSV) and influenza are important pediatric community-acquired (CA) and hospital-acquired (HA) pathogens. The occurrence of pandemic (H1N1) 2009 influenza resulted in additional efforts to intensify infection control (IC) strategies. We detail the impact of IC strategies between 2003 and 2010 on influenza and RSV. Methods: We assessed the rates of CA infections per 100 admissions and HA infections per 1000 patient-days for both RSV and influenza at Children's Memorial Hospital during the winter seasons (September through May) 2003-2010. The season of 2009, however, was extended through June due to ongoing admissions as a result of pandemic (H1N1) 2009 influenza. IC strategies implemented in response to pandemic (H1N1) 2009 influenza are described. The transmission ratio (HA cases/CA cases) was determined and correlated with IC efforts. Results: Substantial season- to-season variability exists for CA RSV and CA influenza rates. The rates of HA RSV and HA influenza and the transmission ratios for these viruses remained unchanged in 2009-10 in comparison to the prior year (at 0.02 and 0.01, respectively) despite implementation of multiple IC strategies. In contrast, since 2005 an inverse association was noted between hand hygiene compliance and the transmission ratio of both RSV and influenza, with Spearman correlation coefficients of -0.84 (p = 0.051) and -0.89 (p = 0.008), respectively. Conclusions: We observed that improvements in hand hygiene compliance correlated with less transmission of RSV and influenza in the hospital. The important role of hand hygiene in preventing transmission of RSV and influenza to hospitalized children should be emphasized.

Original language	English (US)
Pages (from-to)	297-303
Number of pages	7
Journal	Scandinavian Journal of Infectious Diseases
Volume	45
Issue number	4
DOIs	https://doi.org/10.3109/00365548.2012.726738
State	Published - Apr 2013

Funding

ously served on the speaker’ s bureau for Merck, has consulted for Merck and GlaxoSmithKline, has received research support from Merck and Meridian Bioscience, Inc., and has received financial compensation for writing Medscape CME. Dr Shulman has previously served on the speaker’ s bureau for both Merck and GlaxoSmithKline and has served on an advisory board for Merck vaccines and Novartis vaccines. He is currently the chairman of a Data Safety and Monitoring Committee for Pfizer. Dr Noskin is on the advisory board for Theradoc, Inc.The remaining authors have indicated that they have no financial relationships relevant to this article to disclose.

Keywords

Community-acquired infections
Hospital-acquired infections
Nosocomial
Pandemic (H1N1) 2009 influenza
Respiratory syncytial virus

ASJC Scopus subject areas

General Immunology and Microbiology
Microbiology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3109/00365548.2012.726738

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@article{a36283b775f94288b7ea4dad4f971d2e,

title = "The impact of infection control upon hospital-acquired influenza and respiratory syncytial virus",

abstract = "Background: Respiratory syncytial virus (RSV) and influenza are important pediatric community-acquired (CA) and hospital-acquired (HA) pathogens. The occurrence of pandemic (H1N1) 2009 influenza resulted in additional efforts to intensify infection control (IC) strategies. We detail the impact of IC strategies between 2003 and 2010 on influenza and RSV. Methods: We assessed the rates of CA infections per 100 admissions and HA infections per 1000 patient-days for both RSV and influenza at Children's Memorial Hospital during the winter seasons (September through May) 2003-2010. The season of 2009, however, was extended through June due to ongoing admissions as a result of pandemic (H1N1) 2009 influenza. IC strategies implemented in response to pandemic (H1N1) 2009 influenza are described. The transmission ratio (HA cases/CA cases) was determined and correlated with IC efforts. Results: Substantial season- to-season variability exists for CA RSV and CA influenza rates. The rates of HA RSV and HA influenza and the transmission ratios for these viruses remained unchanged in 2009-10 in comparison to the prior year (at 0.02 and 0.01, respectively) despite implementation of multiple IC strategies. In contrast, since 2005 an inverse association was noted between hand hygiene compliance and the transmission ratio of both RSV and influenza, with Spearman correlation coefficients of -0.84 (p = 0.051) and -0.89 (p = 0.008), respectively. Conclusions: We observed that improvements in hand hygiene compliance correlated with less transmission of RSV and influenza in the hospital. The important role of hand hygiene in preventing transmission of RSV and influenza to hospitalized children should be emphasized.",

keywords = "Community-acquired infections, Hospital-acquired infections, Nosocomial, Pandemic (H1N1) 2009 influenza, Respiratory syncytial virus",

author = "Weedon, {Kathryn M.} and Rupp, {Angela H.} and Heffron, {Annie C.} and Kelly, {Sinead Forkan} and Xiaotian Zheng and Shulman, {Stanford T.} and Peggy Gutman and Deli Wang and Ying Zhou and Noskin, {Gary A.} and Anderson, {Evan J.}",

note = "Funding Information: ously served on the speaker{\textquoteright} s bureau for Merck, has consulted for Merck and GlaxoSmithKline, has received research support from Merck and Meridian Bioscience, Inc., and has received financial compensation for writing Medscape CME. Dr Shulman has previously served on the speaker{\textquoteright} s bureau for both Merck and GlaxoSmithKline and has served on an advisory board for Merck vaccines and Novartis vaccines. He is currently the chairman of a Data Safety and Monitoring Committee for Pfizer. Dr Noskin is on the advisory board for Theradoc, Inc.The remaining authors have indicated that they have no financial relationships relevant to this article to disclose.",

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doi = "10.3109/00365548.2012.726738",

language = "English (US)",

volume = "45",

pages = "297--303",

journal = "Scandinavian Journal of Infectious Diseases",

issn = "0036-5548",

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T1 - The impact of infection control upon hospital-acquired influenza and respiratory syncytial virus

AU - Weedon, Kathryn M.

AU - Rupp, Angela H.

AU - Heffron, Annie C.

AU - Kelly, Sinead Forkan

AU - Zheng, Xiaotian

AU - Shulman, Stanford T.

AU - Gutman, Peggy

AU - Wang, Deli

AU - Zhou, Ying

AU - Noskin, Gary A.

AU - Anderson, Evan J.

N1 - Funding Information: ously served on the speaker’ s bureau for Merck, has consulted for Merck and GlaxoSmithKline, has received research support from Merck and Meridian Bioscience, Inc., and has received financial compensation for writing Medscape CME. Dr Shulman has previously served on the speaker’ s bureau for both Merck and GlaxoSmithKline and has served on an advisory board for Merck vaccines and Novartis vaccines. He is currently the chairman of a Data Safety and Monitoring Committee for Pfizer. Dr Noskin is on the advisory board for Theradoc, Inc.The remaining authors have indicated that they have no financial relationships relevant to this article to disclose.

PY - 2013/4

Y1 - 2013/4

N2 - Background: Respiratory syncytial virus (RSV) and influenza are important pediatric community-acquired (CA) and hospital-acquired (HA) pathogens. The occurrence of pandemic (H1N1) 2009 influenza resulted in additional efforts to intensify infection control (IC) strategies. We detail the impact of IC strategies between 2003 and 2010 on influenza and RSV. Methods: We assessed the rates of CA infections per 100 admissions and HA infections per 1000 patient-days for both RSV and influenza at Children's Memorial Hospital during the winter seasons (September through May) 2003-2010. The season of 2009, however, was extended through June due to ongoing admissions as a result of pandemic (H1N1) 2009 influenza. IC strategies implemented in response to pandemic (H1N1) 2009 influenza are described. The transmission ratio (HA cases/CA cases) was determined and correlated with IC efforts. Results: Substantial season- to-season variability exists for CA RSV and CA influenza rates. The rates of HA RSV and HA influenza and the transmission ratios for these viruses remained unchanged in 2009-10 in comparison to the prior year (at 0.02 and 0.01, respectively) despite implementation of multiple IC strategies. In contrast, since 2005 an inverse association was noted between hand hygiene compliance and the transmission ratio of both RSV and influenza, with Spearman correlation coefficients of -0.84 (p = 0.051) and -0.89 (p = 0.008), respectively. Conclusions: We observed that improvements in hand hygiene compliance correlated with less transmission of RSV and influenza in the hospital. The important role of hand hygiene in preventing transmission of RSV and influenza to hospitalized children should be emphasized.

AB - Background: Respiratory syncytial virus (RSV) and influenza are important pediatric community-acquired (CA) and hospital-acquired (HA) pathogens. The occurrence of pandemic (H1N1) 2009 influenza resulted in additional efforts to intensify infection control (IC) strategies. We detail the impact of IC strategies between 2003 and 2010 on influenza and RSV. Methods: We assessed the rates of CA infections per 100 admissions and HA infections per 1000 patient-days for both RSV and influenza at Children's Memorial Hospital during the winter seasons (September through May) 2003-2010. The season of 2009, however, was extended through June due to ongoing admissions as a result of pandemic (H1N1) 2009 influenza. IC strategies implemented in response to pandemic (H1N1) 2009 influenza are described. The transmission ratio (HA cases/CA cases) was determined and correlated with IC efforts. Results: Substantial season- to-season variability exists for CA RSV and CA influenza rates. The rates of HA RSV and HA influenza and the transmission ratios for these viruses remained unchanged in 2009-10 in comparison to the prior year (at 0.02 and 0.01, respectively) despite implementation of multiple IC strategies. In contrast, since 2005 an inverse association was noted between hand hygiene compliance and the transmission ratio of both RSV and influenza, with Spearman correlation coefficients of -0.84 (p = 0.051) and -0.89 (p = 0.008), respectively. Conclusions: We observed that improvements in hand hygiene compliance correlated with less transmission of RSV and influenza in the hospital. The important role of hand hygiene in preventing transmission of RSV and influenza to hospitalized children should be emphasized.

KW - Community-acquired infections

KW - Hospital-acquired infections

KW - Nosocomial

KW - Pandemic (H1N1) 2009 influenza

KW - Respiratory syncytial virus

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The impact of infection control upon hospital-acquired influenza and respiratory syncytial virus

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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