TY - JOUR
T1 - The impact of ischemic cholangiopathy in liver transplantation using donors after cardiac death
T2 - The untold story
AU - Skaro, Anton I.
AU - Jay, Colleen L.
AU - Baker, Talia B.
AU - Wang, Edward
AU - Pasricha, Sarina
AU - Lyuksemburg, Vadim
AU - Martin, John A.
AU - Feinglass, Joseph M.
AU - Preczewski, Luke B.
AU - Abecassis, Michael M.
PY - 2009/10
Y1 - 2009/10
N2 - Background: Liver transplantation (LT) from donation after cardiac death (DCD) donors is increasingly being used to address organ shortages. Despite encouraging reports, standard survival metrics have overestimated the effectiveness of DCD livers. We examined the mode, kinetics, and predictors of organ failure and resource utilization to more fully characterize outcomes after DCD LT. Methods: We reviewed the outcomes for 32 DCD and 237 donation after brain death (DBD) LT recipients at our institution. Results: Recipients of DCD livers had a 2.1 times greater risk of graft failure, a 2.5 times greater risk of relisting, and a 3.2 times greater risk of retransplantation compared with DBD recipients. DCD recipients had a 31.6% higher incidence of biliary complications and a 35.8% higher incidence of ischemic cholangiopathy. Ischemic cholangiography was primarily implicated in the higher risk of graft failure observed after DCD LT. DCD recipients with ischemic cholangiography experienced more frequent rehospitalizations, longer hospital stays, and required more invasive biliary procedures. Conclusion: Related to higher complication rates, DCD recipients necessitated greater resource utilization. This more granular data should be considered in the decision to promote DCD LT. Modification of liver allocation policy is necessary to address those disadvantaged by a failing DCD graft.
AB - Background: Liver transplantation (LT) from donation after cardiac death (DCD) donors is increasingly being used to address organ shortages. Despite encouraging reports, standard survival metrics have overestimated the effectiveness of DCD livers. We examined the mode, kinetics, and predictors of organ failure and resource utilization to more fully characterize outcomes after DCD LT. Methods: We reviewed the outcomes for 32 DCD and 237 donation after brain death (DBD) LT recipients at our institution. Results: Recipients of DCD livers had a 2.1 times greater risk of graft failure, a 2.5 times greater risk of relisting, and a 3.2 times greater risk of retransplantation compared with DBD recipients. DCD recipients had a 31.6% higher incidence of biliary complications and a 35.8% higher incidence of ischemic cholangiopathy. Ischemic cholangiography was primarily implicated in the higher risk of graft failure observed after DCD LT. DCD recipients with ischemic cholangiography experienced more frequent rehospitalizations, longer hospital stays, and required more invasive biliary procedures. Conclusion: Related to higher complication rates, DCD recipients necessitated greater resource utilization. This more granular data should be considered in the decision to promote DCD LT. Modification of liver allocation policy is necessary to address those disadvantaged by a failing DCD graft.
UR - http://www.scopus.com/inward/record.url?scp=70349318209&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=70349318209&partnerID=8YFLogxK
U2 - 10.1016/j.surg.2009.06.052
DO - 10.1016/j.surg.2009.06.052
M3 - Article
C2 - 19789011
AN - SCOPUS:70349318209
SN - 0039-6060
VL - 146
SP - 543
EP - 553
JO - Surgery
JF - Surgery
IS - 4
ER -