The implications of sensitization and kindling for chronic fatigue syndrome

Leonard A. Jason; Matthew Sorenson; Meredyth Evans; Abigail Brown; Samantha Flores; Madison Sunnquist; Charles Schafer

The implications of sensitization and kindling for chronic fatigue syndrome

Leonard A. Jason^*, Matthew Sorenson, Meredyth Evans, Abigail Brown, Samantha Flores, Madison Sunnquist, Charles Schafer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Many patients with chronic fatigue syndrome (CFS) have widespread pain which has a large role in patients' activity limitations. Central sensitization has been posited as an explanation of this pain in both Fibromyalgia (FM) and CFS. Repeated or sustained noxious stimulation can lead to central sensitization, which can cause the spinal cord to enter a "hyperexcitable" state. In this article, we will explore the relevance of the central sensitization theory for CFS, as well as link it to the kindling hypothesis that has been previously offered as one explanation for the etiology of CFS. The article also reviews the implications of this theory for both inflammatory markers and central nervous system involvement.

Original language	English (US)
Title of host publication	Encephalitis, Encephalomyelitis and Encephalopathies
Subtitle of host publication	Symptoms, Causes and Potential Complications
Publisher	Nova Science Publishers, Inc.
Pages	73-93
Number of pages	21
ISBN (Print)	9781622577668
State	Published - Jan 1 2013

Keywords

Chronic fatigue syndrome
Kindling
Limbic-hypothalamic-pituitary axis
Myalgic encephalomyeltits
Sensitization

ASJC Scopus subject areas

Medicine(all)
Neuroscience(all)

Cite this

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AU - Jason, Leonard A.

AU - Sorenson, Matthew

AU - Evans, Meredyth

AU - Brown, Abigail

AU - Flores, Samantha

AU - Sunnquist, Madison

AU - Schafer, Charles

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AB - Many patients with chronic fatigue syndrome (CFS) have widespread pain which has a large role in patients' activity limitations. Central sensitization has been posited as an explanation of this pain in both Fibromyalgia (FM) and CFS. Repeated or sustained noxious stimulation can lead to central sensitization, which can cause the spinal cord to enter a "hyperexcitable" state. In this article, we will explore the relevance of the central sensitization theory for CFS, as well as link it to the kindling hypothesis that has been previously offered as one explanation for the etiology of CFS. The article also reviews the implications of this theory for both inflammatory markers and central nervous system involvement.

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KW - Myalgic encephalomyeltits

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The implications of sensitization and kindling for chronic fatigue syndrome

Abstract

Keywords

ASJC Scopus subject areas

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