The implications of sensitization and kindling for chronic fatigue syndrome

Leonard A. Jason*, Matthew Sorenson, Meredyth Evans, Abigail Brown, Samantha Flores, Madison Sunnquist, Charles Schafer

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations


Many patients with chronic fatigue syndrome (CFS) have widespread pain which has a large role in patients' activity limitations. Central sensitization has been posited as an explanation of this pain in both Fibromyalgia (FM) and CFS. Repeated or sustained noxious stimulation can lead to central sensitization, which can cause the spinal cord to enter a "hyperexcitable" state. In this article, we will explore the relevance of the central sensitization theory for CFS, as well as link it to the kindling hypothesis that has been previously offered as one explanation for the etiology of CFS. The article also reviews the implications of this theory for both inflammatory markers and central nervous system involvement.

Original languageEnglish (US)
Title of host publicationEncephalitis, Encephalomyelitis and Encephalopathies
Subtitle of host publicationSymptoms, Causes and Potential Complications
PublisherNova Science Publishers, Inc.
Number of pages21
ISBN (Print)9781622577668
StatePublished - Jan 1 2013


  • Chronic fatigue syndrome
  • Kindling
  • Limbic-hypothalamic-pituitary axis
  • Myalgic encephalomyeltits
  • Sensitization

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)


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