TY - JOUR
T1 - The Importance of DNA Flow Cytometry in Node-Negative Breast Cancer
AU - Winchester, David J.
AU - Duda, Rosemary B.
AU - August, Carey Z.
AU - Goldschmidt, Robert A.
AU - Wruck, Debra M.
AU - Rademaker, Alfred W.
AU - Winchester, David P.
AU - Merkel, Douglas E.
PY - 1990/7
Y1 - 1990/7
N2 - DNA flow cytometric analysis and conventional clinical factors were compared with disease outcome in 257 patients with node-negative infiltrating ductal carcinoma who had been treated between 1976 and 1983. Median follow-up was 80 months; none of the patients received adjuvant therapy. The relative prognostic importance of clinical variables, ploidy, and S-phase fraction was analyzed by Cox multivariate analysis. Ploidy was analyzable for 198 tumors and did not predict survival. Nuclear grade predicted disease-free survival for all patients. For 71 patients with diploid tumors, only high S-phase had a statistically significant association with relapse. For 127 patients with aneuploid tumors, tumor diameter predicted both disease-free survival and cancer death; histologic grade was also significant for predicting disease-free survival. In conclusion, flow cytometric determination of ploidy and S-phase fraction can provide valuable predictive information in node-negative breast cancer in addition to conventional variables.
AB - DNA flow cytometric analysis and conventional clinical factors were compared with disease outcome in 257 patients with node-negative infiltrating ductal carcinoma who had been treated between 1976 and 1983. Median follow-up was 80 months; none of the patients received adjuvant therapy. The relative prognostic importance of clinical variables, ploidy, and S-phase fraction was analyzed by Cox multivariate analysis. Ploidy was analyzable for 198 tumors and did not predict survival. Nuclear grade predicted disease-free survival for all patients. For 71 patients with diploid tumors, only high S-phase had a statistically significant association with relapse. For 127 patients with aneuploid tumors, tumor diameter predicted both disease-free survival and cancer death; histologic grade was also significant for predicting disease-free survival. In conclusion, flow cytometric determination of ploidy and S-phase fraction can provide valuable predictive information in node-negative breast cancer in addition to conventional variables.
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U2 - 10.1001/archsurg.1990.01410190084013
DO - 10.1001/archsurg.1990.01410190084013
M3 - Article
C2 - 2164372
AN - SCOPUS:0025339582
SN - 0004-0010
VL - 125
SP - 886
EP - 889
JO - Archives of Surgery
JF - Archives of Surgery
IS - 7
ER -
