The Importance of Study Design in the Spine Literature

Adam M. Pearson*, Tor D. Tosteson, James Neil Weinstein

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Careful study design is essential to carry out high quality research that yields valid results. Planning an effective study involves defining the target population, specifying an intervention, selecting appropriate outcome measures, and choosing the appropriate design. Randomized controlled trials, observational cohort studies, and case-control studies all have advantages and disadvantages. When planning or evaluating a study, threats to its validity, including chance, bias, and confounding must be considered. Although the randomized controlled trial may be considered the most valid design, well-designed observational studies often yield similar results. This article reviews these concepts, using examples from the spine literature.

Original languageEnglish (US)
Pages (from-to)202-209
Number of pages8
JournalSeminars in Spine Surgery
Volume21
Issue number4
DOIs
StatePublished - Dec 1 2009

Keywords

  • evidence hierarchy
  • study design
  • validity

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine

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