The Incidence of Amyotrophic Lateral Sclerosis in Ohio 2016-2018: The Ohio Population-Based ALS Registry

Angeline S. Andrew, Erik P. Pioro, Meifang Li, Xun Shi, Jiang Gui, Elijah W. Stommel, Tanya H. Butt, Daniel Peipert, Patricia Henegan, Maeve Tischbein, Pamela Cazzolli, John Novak, Adam Quick, K. Doug Pugar, Komal Sawlani, Bashar Katirji, Todd A. Hayes, D. Kevin Horton, Paul Mehta, Walter G. Bradley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal, neuromuscular disease with no cure. ALS incidence rates have not been assessed specifically in Ohio, yet the state contains both metropolitan and rural areas with a variety of environmental factors that could contribute to disease etiology. We report the incidence of ALS in Ohio residents diagnosed from October 2016 through September 2018. Methods: We engaged practitioners from 9 Ohio sites to identify newly diagnosed ALS patients and to complete case report forms with demographic and clinical information. ALS was diagnosed according to the Awaji criteria and classified as either definite, probable, or possible. We developed a method to estimate missing cases using a Poisson regression model to impute cases in counties with evidence of undercounting. Results: We identified 333 newly diagnosed ALS patients residing in Ohio during the 2-year index period and found incidence rates varied in the 88 state counties. After incorporating the estimated 27% of missing cases, the corrected crude annual incidence was 1.96/100,000 person-years, and the age- and gender-standardized incidence was 1.71/100,000 person-years (standardized to the 2010 US census). Discussion/Conclusion: The estimated Ohio incidence of ALS is overall similar to that reported in other states in the USA. This study reveals a geospatial variation in incidence within the state, and areas with higher rates warrant future investigation.

Original languageEnglish (US)
Pages (from-to)196-205
Number of pages10
Issue number3
StatePublished - Jun 1 2021


  • Amyotrophic lateral sclerosis
  • Epidemiology
  • Hot spots
  • Incidence
  • Ohio

ASJC Scopus subject areas

  • Epidemiology
  • Clinical Neurology


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