The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Wenjie Ren, Maria Virginia Centeno, Sara Berger, Ying Wu, Xiaodong Na, Xianguo Liu, Jyothisri Kondapalli, A. Vania Apkarian, Marco Martina, D. James Surmeier*

*Corresponding author for this work

Research output: Contribution to journalArticle

67 Scopus citations


We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

Original languageEnglish (US)
Pages (from-to)220-222
Number of pages3
JournalNature Neuroscience
Issue number2
StatePublished - Jan 27 2016


ASJC Scopus subject areas

  • Neuroscience(all)

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