The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Wenjie Ren; Maria Virginia Centeno; Sara Berger; Ying Wu; Xiaodong Na; Xianguo Liu; Jyothisri Kondapalli; A. Vania Apkarian; Marco Martina; D. James Surmeier

doi:10.1038/nn.4199

The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Wenjie Ren, Maria Virginia Centeno, Sara Berger, Ying Wu, Xiaodong Na, Xianguo Liu, Jyothisri Kondapalli, A. Vania Apkarian, Marco Martina, D. James Surmeier^*

^*Corresponding author for this work

Physiology

Research output: Contribution to journal › Article

67 Scopus citations

Abstract

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

Original language	English (US)
Pages (from-to)	220-222
Number of pages	3
Journal	Nature Neuroscience
Volume	19
Issue number	2
DOIs	https://doi.org/10.1038/nn.4199
State	Published - Jan 27 2016

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Neuroscience(all)

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Ren, W., Centeno, M. V., Berger, S., Wu, Y., Na, X., Liu, X., Kondapalli, J., Apkarian, A. V., Martina, M., & Surmeier, D. J. (2016). The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain. Nature Neuroscience, 19(2), 220-222. https://doi.org/10.1038/nn.4199

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