Abstract
We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 220-222 |
| Number of pages | 3 |
| Journal | Nature Neuroscience |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jan 27 2016 |
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ASJC Scopus subject areas
- Neuroscience(all)
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The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain. / Ren, Wenjie; Centeno, Maria Virginia; Berger, Sara; Wu, Ying; Na, Xiaodong; Liu, Xianguo; Kondapalli, Jyothisri; Apkarian, Apkar; Martina, Marco; Surmeier Jr, Dalton James.
In: Nature Neuroscience, Vol. 19, No. 2, 27.01.2016, p. 220-222.Research output: Contribution to journal › Article
TY - JOUR
T1 - The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain
AU - Ren, Wenjie
AU - Centeno, Maria Virginia
AU - Berger, Sara
AU - Wu, Ying
AU - Na, Xiaodong
AU - Liu, Xianguo
AU - Kondapalli, Jyothisri
AU - Apkarian, Apkar
AU - Martina, Marco
AU - Surmeier Jr, Dalton James
PY - 2016/1/27
Y1 - 2016/1/27
N2 - We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.
AB - We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.
UR - http://www.scopus.com/inward/record.url?scp=84956686547&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84956686547&partnerID=8YFLogxK
U2 - 10.1038/nn.4199
DO - 10.1038/nn.4199
M3 - Article
C2 - 26691834
AN - SCOPUS:84956686547
VL - 19
SP - 220
EP - 222
JO - Nature Neuroscience
JF - Nature Neuroscience
SN - 1097-6256
IS - 2
ER -