The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain

Wenjie Ren, Maria Virginia Centeno, Sara Berger, Ying Wu, Xiaodong Na, Xianguo Liu, Jyothisri Kondapalli, Apkar Apkarian, Marco Martina, Dalton James Surmeier Jr*

*Corresponding author for this work

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.

Original languageEnglish (US)
Pages (from-to)220-222
Number of pages3
JournalNature Neuroscience
Volume19
Issue number2
DOIs
StatePublished - Jan 27 2016

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Nucleus Accumbens
Neuralgia
Neurons
Peripheral Nerve Injuries
Hyperalgesia
Wounds and Injuries
Pain

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Ren, Wenjie ; Centeno, Maria Virginia ; Berger, Sara ; Wu, Ying ; Na, Xiaodong ; Liu, Xianguo ; Kondapalli, Jyothisri ; Apkarian, Apkar ; Martina, Marco ; Surmeier Jr, Dalton James. / The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain. In: Nature Neuroscience. 2016 ; Vol. 19, No. 2. pp. 220-222.
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The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain. / Ren, Wenjie; Centeno, Maria Virginia; Berger, Sara; Wu, Ying; Na, Xiaodong; Liu, Xianguo; Kondapalli, Jyothisri; Apkarian, Apkar; Martina, Marco; Surmeier Jr, Dalton James.

In: Nature Neuroscience, Vol. 19, No. 2, 27.01.2016, p. 220-222.

Research output: Contribution to journalArticle

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