@article{b17fb5adf22c448b9393ea94338d79b1,
title = "The indirect pathway of the nucleus accumbens shell amplifies neuropathic pain",
abstract = "We examined adaptations in nucleus accumbens (NAc) neurons in mouse and rat peripheral nerve injury models of neuropathic pain. Injury selectively increased excitability of NAc shell indirect pathway spiny projection neurons (iSPNs) and altered their synaptic connectivity. Moreover, injury-induced tactile allodynia was reversed by inhibiting and exacerbated by exciting iSPNs, indicating that they not only participated in the central representation of pain, but gated activity in ascending nociceptive pathways.",
author = "Wenjie Ren and Centeno, {Maria Virginia} and Sara Berger and Ying Wu and Xiaodong Na and Xianguo Liu and Jyothisri Kondapalli and Apkarian, {A. Vania} and Marco Martina and Surmeier, {D. James}",
note = "Funding Information: We thank the laboratory of S.M. Sternson (Howard Hughes Medical Institute) for providing technical help and chemical compound PSEM89S, and H. Fields for critically reading an earlier version of the manuscript. This work was supported by US National Institutes of Health grants DE022746 (A.V.A.), NS064091 (M.M.), NS 34696 and JPB Foundation (D.J.S.), and National Natural Science Foundation of China U1201223 (X.L.).",
year = "2016",
month = jan,
day = "27",
doi = "10.1038/nn.4199",
language = "English (US)",
volume = "19",
pages = "220--222",
journal = "Nature Neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "2",
}