The induction of mixed chimerism using ES cell-derived hematopoietic stem cells

Francesca Milanetti, You Hong Cheng, Richard K Burt*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The use of hematopoietic stem cell (HSC) transplantation for the establishment of mixed chimerism generally leads to durable immune tolerance to allografts in animal models of transplantation. The development of reduced intensity regimens for achieving allogeneic hematopoietic engraftment across major histocompatibility complex (MHC) barriers and its recent application in clinical trials of kidney transplantation is encouraging. Embryonic stem cell-derived HSCs have lower immunogenicity and could, therefore, potentially be safer, inducing mixed chimerism and tolerance with minimal host pre-treatment and risk of graft versus host disease, despite crossing MHC barriers.

Original languageEnglish (US)
Title of host publicationThe Immunological Barriers to Regenerative Medicine
PublisherSpringer New York
Pages225-255
Number of pages31
ISBN (Electronic)9781461454809
ISBN (Print)9781461454793
DOIs
StatePublished - Jan 1 2013

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Milanetti, F., Cheng, Y. H., & Burt, R. K. (2013). The induction of mixed chimerism using ES cell-derived hematopoietic stem cells. In The Immunological Barriers to Regenerative Medicine (pp. 225-255). Springer New York. https://doi.org/10.1007/978-1-4614-5480-9_12