The induction of tolerance to alloantigens using HLA-based synthetic peptides

Alan M. Krensky*, Carol Clayberger

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

The identification of immunomodulatory approaches that allow the induction of antigen-specific unresponsiveness is required for long-term graft survival without the complications of chronic immunosuppression. Recent novel strategies based upon treatment with synthetic peptides corresponding to linear sequences of MHC class 1 and II molecules reproducibly induce tolerance to alloantigens. Although the mechanisms involved are still not completely understood, the phenomenology reported makes these approaches promising for evaluation in clinical trials.

Original languageEnglish (US)
Pages (from-to)791-796
Number of pages6
JournalCurrent Opinion in Immunology
Volume6
Issue number5
DOIs
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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