The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: Results of a one-year exercise intervention

Michelle W. Voss*, Susie Heo, Ruchika S. Prakash, Kirk I. Erickson, Heloisa Alves, Laura Chaddock, Amanda N. Szabo, Emily L. Mailey, Thomas R. Wójcicki, Siobhan M. White, Neha Gothe, Edward Mcauley, Bradley P. Sutton, Arthur F. Kramer

*Corresponding author for this work

Research output: Contribution to journalArticle

235 Citations (Scopus)

Abstract

Cerebral white matter (WM) degeneration occurs with increasing age and is associated with declining cognitive function. Research has shown that cardiorespiratory fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to WM integrity in the context of a one-year exercise intervention. Further, we examined the pattern of diffusivity changes to better understand the underlying biological mechanisms. Finally, we assessed whether training-induced changes in WM integrity would be associated with improvements in cognitive performance independent of aerobic fitness gains. Results showed that aerobic fitness training did not affect group-level change in WM integrity, executive function, or short-term memory, but that greater aerobic fitness derived from the walking program was associated with greater change in WM integrity in the frontal and temporal lobes, and greater improvement in short-term memory. Increases in WM integrity, however, were not associated with short-term memory improvement, independent of fitness improvements. Therefore, while not all findings are consistent with previous research, we provide novel evidence for correlated change in training-induced aerobic fitness, WM integrity, and cognition among healthy older adults.

Original languageEnglish (US)
Pages (from-to)2972-2985
Number of pages14
JournalHuman Brain Mapping
Volume34
Issue number11
DOIs
StatePublished - Nov 1 2013

Fingerprint

Cognition
Short-Term Memory
Executive Function
Frontal Lobe
Temporal Lobe
White Matter
Research
Walking

Keywords

  • Aging
  • Anisotropy
  • Cerebrum
  • Cognition
  • Diffusion tensor imaging
  • Physical fitness

ASJC Scopus subject areas

  • Anatomy
  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology

Cite this

Voss, Michelle W. ; Heo, Susie ; Prakash, Ruchika S. ; Erickson, Kirk I. ; Alves, Heloisa ; Chaddock, Laura ; Szabo, Amanda N. ; Mailey, Emily L. ; Wójcicki, Thomas R. ; White, Siobhan M. ; Gothe, Neha ; Mcauley, Edward ; Sutton, Bradley P. ; Kramer, Arthur F. / The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults : Results of a one-year exercise intervention. In: Human Brain Mapping. 2013 ; Vol. 34, No. 11. pp. 2972-2985.
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Voss, MW, Heo, S, Prakash, RS, Erickson, KI, Alves, H, Chaddock, L, Szabo, AN, Mailey, EL, Wójcicki, TR, White, SM, Gothe, N, Mcauley, E, Sutton, BP & Kramer, AF 2013, 'The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults: Results of a one-year exercise intervention', Human Brain Mapping, vol. 34, no. 11, pp. 2972-2985. https://doi.org/10.1002/hbm.22119

The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults : Results of a one-year exercise intervention. / Voss, Michelle W.; Heo, Susie; Prakash, Ruchika S.; Erickson, Kirk I.; Alves, Heloisa; Chaddock, Laura; Szabo, Amanda N.; Mailey, Emily L.; Wójcicki, Thomas R.; White, Siobhan M.; Gothe, Neha; Mcauley, Edward; Sutton, Bradley P.; Kramer, Arthur F.

In: Human Brain Mapping, Vol. 34, No. 11, 01.11.2013, p. 2972-2985.

Research output: Contribution to journalArticle

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T1 - The influence of aerobic fitness on cerebral white matter integrity and cognitive function in older adults

T2 - Results of a one-year exercise intervention

AU - Voss, Michelle W.

AU - Heo, Susie

AU - Prakash, Ruchika S.

AU - Erickson, Kirk I.

AU - Alves, Heloisa

AU - Chaddock, Laura

AU - Szabo, Amanda N.

AU - Mailey, Emily L.

AU - Wójcicki, Thomas R.

AU - White, Siobhan M.

AU - Gothe, Neha

AU - Mcauley, Edward

AU - Sutton, Bradley P.

AU - Kramer, Arthur F.

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Cerebral white matter (WM) degeneration occurs with increasing age and is associated with declining cognitive function. Research has shown that cardiorespiratory fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to WM integrity in the context of a one-year exercise intervention. Further, we examined the pattern of diffusivity changes to better understand the underlying biological mechanisms. Finally, we assessed whether training-induced changes in WM integrity would be associated with improvements in cognitive performance independent of aerobic fitness gains. Results showed that aerobic fitness training did not affect group-level change in WM integrity, executive function, or short-term memory, but that greater aerobic fitness derived from the walking program was associated with greater change in WM integrity in the frontal and temporal lobes, and greater improvement in short-term memory. Increases in WM integrity, however, were not associated with short-term memory improvement, independent of fitness improvements. Therefore, while not all findings are consistent with previous research, we provide novel evidence for correlated change in training-induced aerobic fitness, WM integrity, and cognition among healthy older adults.

AB - Cerebral white matter (WM) degeneration occurs with increasing age and is associated with declining cognitive function. Research has shown that cardiorespiratory fitness and exercise are effective as protective, even restorative, agents against cognitive and neurobiological impairments in older adults. In this study, we investigated whether the beneficial impact of aerobic fitness would extend to WM integrity in the context of a one-year exercise intervention. Further, we examined the pattern of diffusivity changes to better understand the underlying biological mechanisms. Finally, we assessed whether training-induced changes in WM integrity would be associated with improvements in cognitive performance independent of aerobic fitness gains. Results showed that aerobic fitness training did not affect group-level change in WM integrity, executive function, or short-term memory, but that greater aerobic fitness derived from the walking program was associated with greater change in WM integrity in the frontal and temporal lobes, and greater improvement in short-term memory. Increases in WM integrity, however, were not associated with short-term memory improvement, independent of fitness improvements. Therefore, while not all findings are consistent with previous research, we provide novel evidence for correlated change in training-induced aerobic fitness, WM integrity, and cognition among healthy older adults.

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KW - Anisotropy

KW - Cerebrum

KW - Cognition

KW - Diffusion tensor imaging

KW - Physical fitness

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