TY - JOUR
T1 - The influence of changing dose rate patterns from inhaled beta-gamma emitting radionuclide on lung cancer
AU - Puukila, Stephanie
AU - Thome, Christopher
AU - Brooks, Antone L.
AU - Woloschak, Gayle
AU - Boreham, Douglas R.
N1 - Funding Information:
This work was supported by an industrial research grant from Bruce Power [212832] and Mitacs [IT06447]. We would like to thank Dr. Benjamin Haley and Dr. Tatjana Paunesku from Northwestern University for their aid in obtaining the data and Dr. Dani Dixon from Flinders University for her aid in analyzing the data. We would also like to thank the entire ITRI team who conduct all of the original experimentation and analysis that made this work possible. The underlying research materials for this article can be accessed at http://janus.northwestern.edu/lovelace/data.php
Funding Information:
This work was supported by an industrial research grant from Bruce Power [212832] and Mitacs [IT06447].
Publisher Copyright:
© 2018, © 2018 Taylor & Francis Group, LLC.
PY - 2018/11/2
Y1 - 2018/11/2
N2 - Purpose: Dose and dose rate are both appropriate for estimating risk from internally deposited radioactive materials. We investigated the role of dose rate on lung cancer induction in Beagle dogs following a single inhalation of strontium-90 (90Sr), cerium-144 (144Ce), yttrium-91 (91Y), or yttrium-90 (90Y). As retention of the radionuclide is dependent on biological clearance and physical half-life a representative quantity to describe this complex changing dose rate is needed. Materials and methods: Data were obtained from Beagle dog experiments from the Inhalation Toxicology Research Institute. The authors selected the dose rate at the effective half-life of each radionuclide (DRef). Results: Dogs exposed to DRef (1–100 Gy/day) died within the first year after exposure from acute lung disease. Dogs exposed at lower DRef (0.1–10 Gy/day) died of lung cancer. As DRef decreased further (<0.1 Gy/day 90Sr, <0.5 Gy/day 144Ce, <0.9 Gy/day 91Y, <8 Gy/day 90Y), survival and lung cancer frequency were not significantly different from control dogs. Conclusion: Radiation exposures resulting from inhalation of beta-gamma emitting radionuclides that decay at different rates based on their effective half-life, leading to different rates of decrease in dose rate and cumulative dose, is less effective in causing cancer than acute low linear energy transfer exposures of the lung.
AB - Purpose: Dose and dose rate are both appropriate for estimating risk from internally deposited radioactive materials. We investigated the role of dose rate on lung cancer induction in Beagle dogs following a single inhalation of strontium-90 (90Sr), cerium-144 (144Ce), yttrium-91 (91Y), or yttrium-90 (90Y). As retention of the radionuclide is dependent on biological clearance and physical half-life a representative quantity to describe this complex changing dose rate is needed. Materials and methods: Data were obtained from Beagle dog experiments from the Inhalation Toxicology Research Institute. The authors selected the dose rate at the effective half-life of each radionuclide (DRef). Results: Dogs exposed to DRef (1–100 Gy/day) died within the first year after exposure from acute lung disease. Dogs exposed at lower DRef (0.1–10 Gy/day) died of lung cancer. As DRef decreased further (<0.1 Gy/day 90Sr, <0.5 Gy/day 144Ce, <0.9 Gy/day 91Y, <8 Gy/day 90Y), survival and lung cancer frequency were not significantly different from control dogs. Conclusion: Radiation exposures resulting from inhalation of beta-gamma emitting radionuclides that decay at different rates based on their effective half-life, leading to different rates of decrease in dose rate and cumulative dose, is less effective in causing cancer than acute low linear energy transfer exposures of the lung.
KW - Dose rate
KW - inhaled radionuclides
KW - radiation
KW - radiation-induced lung cancer
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U2 - 10.1080/09553002.2018.1511929
DO - 10.1080/09553002.2018.1511929
M3 - Article
C2 - 30257126
AN - SCOPUS:85053923134
SN - 0955-3002
VL - 94
SP - 955
EP - 966
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 11
ER -
