Der Einfluß von schwerem Wasser auf das stationäre Strom-Spannungsverhalten des Ranvierschen Schnürrings

Translated title of the contribution: The influence of heavy water on the stationary current-voltage characteristic of the ranvier node

H. Müller-Mohnssen*, G. Albrecht-Bühler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A substitution of H2O by D2O in the extracellular Ringer's solution leads to the following changes in the current-voltage-relation of the Ranvier node: 1. The positive resistances are increased by a factor of 1.2. 2. The transition-region of the limiting values of resistance is shifted 20 mV towards depolarizing potentials. From 1. and 2. there results an increase of the negative differential resistance which is observed if the membrane potential exceeds+20 mV. These changes are observed independently of whether the current is carried by K (or Rb), or (during Veratridin-depolarization) also by Na, Li or NH4 . This effect of D2O is comparable to the influence of increased extracellular concentration of H and Ca•• as well as to increased osmolarity. All lead to increased threshold voltage of action potential according to the shift of transition-region to more positive potentials. It is shown that an explanation of the dominant influence of D2O based merely on the differences in physico-chemical properties between H2O- and D2O-Ringer's solution is very unlikely. Therefore the results are understood as consequences of an influence of solvent on the excitable membrane itself. This interpretation is supported by the observation that the microscopical picture of nerve fibres, circulated with D2O-solutions, changes in a definite manner.

Translated title of the contributionThe influence of heavy water on the stationary current-voltage characteristic of the ranvier node
Original languageGerman
Pages (from-to)65-75
Number of pages11
JournalPflügers Archiv European Journal of Physiology
Volume305
Issue number1
DOIs
StatePublished - Mar 1 1968

Keywords

  • DO-Effects
  • Electrophysiology
  • Excitable Membrane
  • Ranvier Node
  • Stationary Current-Voltage Characteristic

ASJC Scopus subject areas

  • Physiology

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