The influence of intensity standardization on medical image registration

Ulaş Baǧci, Jayaram K. Udupa, Li Bai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

5 Scopus citations

Abstract

Acquisition-to-acquisition signal intensity variations (non-standardness) are inherent in MR images. Standardization is a post processing method for correcting inter-subject intensity variations through transforming all images from the given image gray scale into a standard gray scale wherein similar intensities achieve similar tissue meanings. The lack of a standard image intensity scale in MRI leads to many difficulties in tissue characterizability, image display, and analysis, including image segmentation. This phenomenon has been documented well; however, effects of standardization on medical image registration have not been studied yet. In this paper, we investigate the influence of intensity standardization in registration tasks with systematic and analytic evaluations involving clinical MR images. We conducted nearly 20,000 clinical MR image registration experiments and evaluated the quality of registrations both quantitatively and qualitatively. The evaluations show that intensity variations between images degrades the accuracy of registration performance. The results imply that the accuracy of image registration not only depends on spatial and geometric similarity but also on the similarity of the intensity values for the same tissues in different images.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2010
Subtitle of host publicationVisualization, Image-Guided Procedures, and Modeling
EditorsKenneth H. Wong, Michael I. Miga
PublisherSPIE
ISBN (Electronic)9780819480262
DOIs
StatePublished - 2010
Externally publishedYes
EventMedical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling - San Diego, United States
Duration: Feb 14 2010Feb 16 2010

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7625
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2010: Visualization, Image-Guided Procedures, and Modeling
CountryUnited States
CitySan Diego
Period2/14/102/16/10

Keywords

  • Image registration
  • Inhomogeneity correction
  • Intensity standardization
  • Non-standardness
  • Quantitative validation

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'The influence of intensity standardization on medical image registration'. Together they form a unique fingerprint.

Cite this