The influence of naloxone on disorders of the cardiac rhythm and heart conduction system

E. V. Shlyakhto, A. A. Zaitsev, A. V. Panov, A. V. Ardashev, E. M. Nifontov, E. A. Kashina, V. V. Kazarin, V. V. Ivanov

Research output: Contribution to journalArticlepeer-review

Abstract

In experimental arrhythmias induced in rabbits by strophanthin, epinephrine, and calcium chloride the high antiarrhythmic efficacy of Naloxone was proved. No antiarrhythmic activity of Naloxone was observed in aconitine models. The intravenous administration of Naloxone to normal adults (0.4-0.8 mg) increased the sinus cycle length, sinus node recovery time (SNRT), CSNRT, and sinoatrial conduction time.

Original languageEnglish (US)
Pages (from-to)36
Number of pages1
JournalEksperimental'naya i Klinicheskaya Farmakologiya
Volume59
Issue number3
StatePublished - 1996

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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