The influence of 18flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma

Jason W. Smith; Jonathan Moreira; Gerard Abood; Gerard V. Aranha; Suneel Nagda; Robert H. Wagner; Margo Shoup

doi:10.1016/j.amjsurg.2008.10.010

The influence of ¹⁸flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma

Jason W. Smith, Jonathan Moreira, Gerard Abood, Gerard V. Aranha, Suneel Nagda, Robert H. Wagner, Margo Shoup^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Background: The influence of positron emission tomography (PET) scanning with flourodeoxyglucose (FDG) on decision making for the treatment of patients with esophagogastric junction (EGJ) carcinoma is unclear as is the utility of the maximum standardized uptake value (SUV) as a prognostic indicator. Methods: This study was a retrospective review of EGJ carcinoma cases at a single institution during a 5-year period. Results: FDG-PET altered treatment in 13 of 64 patients (20%). Of these, 21 patients had PET scans before and after undergoing neoadjuvant chemoradiation (CRT) as well as surgery. Patients who had a decrease in SUV >50% had a 12-month disease-free survival advantage over patients a decrease in SUV <50% (93% vs 43%, P = .025). Conclusions: FDG-PET alters treatment in a significant number of patients with EGJ carcinoma. A >50% decrease in SUV after CRT is associated with an improved prognosis.

Original language	English (US)
Pages (from-to)	308-312
Number of pages	5
Journal	American Journal of Surgery
Volume	197
Issue number	3
DOIs	https://doi.org/10.1016/j.amjsurg.2008.10.010
State	Published - Mar 1 2009

Keywords

Esophageal carcinoma
Esophagectomy
Esophagogastric junction
FDG-JPET
Gastric carcinoma

ASJC Scopus subject areas

Surgery

Access to Document

10.1016/j.amjsurg.2008.10.010

Cite this

@article{2eded0e3b647489da0f446d104e6f70b,

title = "The influence of 18flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma",

abstract = "Background: The influence of positron emission tomography (PET) scanning with flourodeoxyglucose (FDG) on decision making for the treatment of patients with esophagogastric junction (EGJ) carcinoma is unclear as is the utility of the maximum standardized uptake value (SUV) as a prognostic indicator. Methods: This study was a retrospective review of EGJ carcinoma cases at a single institution during a 5-year period. Results: FDG-PET altered treatment in 13 of 64 patients (20%). Of these, 21 patients had PET scans before and after undergoing neoadjuvant chemoradiation (CRT) as well as surgery. Patients who had a decrease in SUV >50% had a 12-month disease-free survival advantage over patients a decrease in SUV <50% (93% vs 43%, P = .025). Conclusions: FDG-PET alters treatment in a significant number of patients with EGJ carcinoma. A >50% decrease in SUV after CRT is associated with an improved prognosis.",

keywords = "Esophageal carcinoma, Esophagectomy, Esophagogastric junction, FDG-JPET, Gastric carcinoma",

author = "Smith, {Jason W.} and Jonathan Moreira and Gerard Abood and Aranha, {Gerard V.} and Suneel Nagda and Wagner, {Robert H.} and Margo Shoup",

year = "2009",

month = mar,

day = "1",

doi = "10.1016/j.amjsurg.2008.10.010",

language = "English (US)",

volume = "197",

pages = "308--312",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier Inc.",

number = "3",

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TY - JOUR

T1 - The influence of 18flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma

AU - Smith, Jason W.

AU - Moreira, Jonathan

AU - Abood, Gerard

AU - Aranha, Gerard V.

AU - Nagda, Suneel

AU - Wagner, Robert H.

AU - Shoup, Margo

PY - 2009/3/1

Y1 - 2009/3/1

N2 - Background: The influence of positron emission tomography (PET) scanning with flourodeoxyglucose (FDG) on decision making for the treatment of patients with esophagogastric junction (EGJ) carcinoma is unclear as is the utility of the maximum standardized uptake value (SUV) as a prognostic indicator. Methods: This study was a retrospective review of EGJ carcinoma cases at a single institution during a 5-year period. Results: FDG-PET altered treatment in 13 of 64 patients (20%). Of these, 21 patients had PET scans before and after undergoing neoadjuvant chemoradiation (CRT) as well as surgery. Patients who had a decrease in SUV >50% had a 12-month disease-free survival advantage over patients a decrease in SUV <50% (93% vs 43%, P = .025). Conclusions: FDG-PET alters treatment in a significant number of patients with EGJ carcinoma. A >50% decrease in SUV after CRT is associated with an improved prognosis.

AB - Background: The influence of positron emission tomography (PET) scanning with flourodeoxyglucose (FDG) on decision making for the treatment of patients with esophagogastric junction (EGJ) carcinoma is unclear as is the utility of the maximum standardized uptake value (SUV) as a prognostic indicator. Methods: This study was a retrospective review of EGJ carcinoma cases at a single institution during a 5-year period. Results: FDG-PET altered treatment in 13 of 64 patients (20%). Of these, 21 patients had PET scans before and after undergoing neoadjuvant chemoradiation (CRT) as well as surgery. Patients who had a decrease in SUV >50% had a 12-month disease-free survival advantage over patients a decrease in SUV <50% (93% vs 43%, P = .025). Conclusions: FDG-PET alters treatment in a significant number of patients with EGJ carcinoma. A >50% decrease in SUV after CRT is associated with an improved prognosis.

KW - Esophageal carcinoma

KW - Esophagectomy

KW - Esophagogastric junction

KW - FDG-JPET

KW - Gastric carcinoma

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