The influence of 18flourodeoxyglucose positron emission tomography on the management of gastroesophageal junction carcinoma

Jason W. Smith, Jonathan Moreira, Gerard Abood, Gerard V. Aranha, Suneel Nagda, Robert H. Wagner, Margo Shoup*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: The influence of positron emission tomography (PET) scanning with flourodeoxyglucose (FDG) on decision making for the treatment of patients with esophagogastric junction (EGJ) carcinoma is unclear as is the utility of the maximum standardized uptake value (SUV) as a prognostic indicator. Methods: This study was a retrospective review of EGJ carcinoma cases at a single institution during a 5-year period. Results: FDG-PET altered treatment in 13 of 64 patients (20%). Of these, 21 patients had PET scans before and after undergoing neoadjuvant chemoradiation (CRT) as well as surgery. Patients who had a decrease in SUV >50% had a 12-month disease-free survival advantage over patients a decrease in SUV <50% (93% vs 43%, P = .025). Conclusions: FDG-PET alters treatment in a significant number of patients with EGJ carcinoma. A >50% decrease in SUV after CRT is associated with an improved prognosis.

Original languageEnglish (US)
Pages (from-to)308-312
Number of pages5
JournalAmerican Journal of Surgery
Volume197
Issue number3
DOIs
StatePublished - Mar 1 2009

Keywords

  • Esophageal carcinoma
  • Esophagectomy
  • Esophagogastric junction
  • FDG-JPET
  • Gastric carcinoma

ASJC Scopus subject areas

  • Surgery

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