The Ins and outs of HIV Rev

Thomas J. Hope

doi:10.1006/abbi.1999.1207

The Ins and outs of HIV Rev

Thomas J. Hope^*

^*Corresponding author for this work

Cell & Developmental Biology

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

The Rev protein of the human immunodeficiency virus mediates the nuclear export of the intron-containing viral messages. This export is a consequence of the continuous shuttling of HIV Rev between the nucleus and cytoplasm. This shuttling is mediated by a nuclear localization signal and a nuclear export signal contained within Rev. Recently, several factors which are required for the movement of Rev through the nuclear pore have been identified. This review will focus on these factors and their role the nucleocytoplasmic shuttling of HIV Rev.

Original language	English (US)
Pages (from-to)	186-191
Number of pages	6
Journal	Archives of biochemistry and biophysics
Volume	365
Issue number	2
DOIs	https://doi.org/10.1006/abbi.1999.1207
State	Published - May 15 1999

Funding

The author thanks the members of the Hope laboratory for the critical reading of the manuscript and Allison Bocksruker for secretarial assistance. T.J.H. is supported by NIH Grant RO1AI35477 and the Gene and Ruth Posner Foundation.

ASJC Scopus subject areas

Molecular Biology
Biophysics
Biochemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1006/abbi.1999.1207

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author = "Hope, {Thomas J.}",

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The Ins and outs of HIV Rev

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

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