The Interaction of Obesity and Metabolic Syndrome in Determining Risk of Complication Following Total Joint Arthroplasty

Adam I. Edelstein, Linda I. Suleiman, Andrew P. Alvarez, Ryan M. Sacotte, Charles D. Qin, Matthew Dean Beal, David W. Manning*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


Background The arthroplasty population is increasingly comorbid, and current quality improvement initiatives demand accurate risk stratification. Metabolic syndrome (MetS) has been identified as a risk factor for adverse events after arthroplasty; however, its interaction with obesity in contributing to risk is unclear. Methods A retrospective analysis of all Medicare patients undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) at a single institution from 2009 to 2013 investigated the interaction between MetS, body mass index (BMI), and risk for Centers for Medicare and Medicaid Services (CMS)–reportable complications, readmission, and discharge disposition. Results A total of 1462 patients (942 TKA, 538 THA) were included, of which 16.2% had MetS. Regression analysis found that MetS was significantly related to risk of CMS complications (odds ratio [OR] = 1.96, 95% confidence interval [CI] 1.16-3.31, P = .012) and nonhome discharge (OR = 1.78, 95% CI 1.39-2.27, P < .001), but not readmission (OR = 1.23, 95% CI 0.7-2.18, P = .485). Within the MetS cohort, increasing BMI was not associated with increasing complications (P = .726) or readmissions (P = .206) but was associated with nonhome discharge (OR = 1.191 per unit increase in BMI, 95% CI 1.038-1.246, P = .001). Conclusion MetS increases risk for CMS-reportable complications and nonhome discharge disposition after THA and TKA regardless of BMI. Obesity is of less value than MetS in assessing overall risk for complication after THA and TKA.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalJournal of Arthroplasty
Issue number9
StatePublished - Sep 1 2016


  • BMI
  • complications
  • metabolic syndrome
  • obesity

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine


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