The international collaborative on fatigue following infection (COFFI)

Ben Z. Katz; Simon M. Collin; Gabrielle Murphy; Rona Moss-Morris; Vegard Bruun Wyller; Knut Arne Wensaas; Jeannine L.A. Hautvast; Chantal P. Bleeker-Rovers; Ute Vollmer-Conna; Dedra Buchwald; Renée Taylor; Paul Little; Esther Crawley; Peter D. White; Andrew Lloyd

doi:10.1080/21641846.2018.1426086

The international collaborative on fatigue following infection (COFFI)

Ben Z. Katz^*, Simon M. Collin, Gabrielle Murphy, Rona Moss-Morris, Vegard Bruun Wyller, Knut Arne Wensaas, Jeannine L.A. Hautvast, Chantal P. Bleeker-Rovers, Ute Vollmer-Conna, Dedra Buchwald, Renée Taylor, Paul Little, Esther Crawley, Peter D. White, Andrew Lloyd

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilising COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF. Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. The 9 cohorts closed to recruitment total over 3000 participants, including nearly 1000 with infectious mononucleosis (IM), > 500 with Q fever, > 800 with giardiasis, > 600 with campylobacter gastroenteritis (CG), 190 with Legionnaires disease and 60 with Ross River virus. Follow-ups have been at least 6 months and up to 10 years. All studies use the Fukuda criteria for defining chronic fatigue syndrome (CFS). Results: Preliminary analyses indicated that risk factors for non-recovery from PIF included lower physical fitness, female gender, severity of the acute sickness response, and autonomic dysfunction. Conclusions: COFFI (https://internationalcoffi.wordpress.com/) is an international collaboration which should be able to answer questions based on pooled data that are not answerable in the individual cohorts. Possible questions may include the following: Do different infections trigger different PIF syndromes (e.g. CFS vs. irritable bowel syndrome)?; What are longitudinal predictors of PIF and its severity?.

Original language	English (US)
Pages (from-to)	106-121
Number of pages	16
Journal	Fatigue: Biomedicine, Health and Behavior
Volume	6
Issue number	2
DOIs	https://doi.org/10.1080/21641846.2018.1426086
State	Published - Apr 3 2018

Funding

The London meeting at which the COFFI collaborative was established was generously funded by the Sue Esterman Fund, a donor advised fund managed by the London Community Foundation whose website is Londoncf.org.uk. DIOS/SIOS were supported by funding from the Mason Foundation and the National Health and Medical Research Council of Australia (Project Grants 157092 and 157062) and a Cooperative Research Agreement with the US Centers for Disease Control and Prevention (U50/CCU019851-01). The prospective study of CFS following IM was funded by the National Institutes of Health (AI 105781). COFFI would also like to thank Paul Burton (University of Bristol) and Caroline Sabin (University College of London) for their presentations on data sharing and collaborative endeavors, respectively. AL is supported by a NHMRC Practitioner Fellowship (1043067).

Keywords

Chronic fatigue syndrome
Legionnaire's disease
Q fever
gastroenteritis
infectious mononucleosis

ASJC Scopus subject areas

Medicine (miscellaneous)
Public Health, Environmental and Occupational Health
Behavioral Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/21641846.2018.1426086

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Katz, B. Z., Collin, S. M., Murphy, G., Moss-Morris, R., Wyller, V. B., Wensaas, K. A., Hautvast, J. L. A., Bleeker-Rovers, C. P., Vollmer-Conna, U., Buchwald, D., Taylor, R., Little, P., Crawley, E., White, P. D., & Lloyd, A. (2018). The international collaborative on fatigue following infection (COFFI). Fatigue: Biomedicine, Health and Behavior, 6(2), 106-121. https://doi.org/10.1080/21641846.2018.1426086

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abstract = "Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilising COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF. Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. The 9 cohorts closed to recruitment total over 3000 participants, including nearly 1000 with infectious mononucleosis (IM), > 500 with Q fever, > 800 with giardiasis, > 600 with campylobacter gastroenteritis (CG), 190 with Legionnaires disease and 60 with Ross River virus. Follow-ups have been at least 6 months and up to 10 years. All studies use the Fukuda criteria for defining chronic fatigue syndrome (CFS). Results: Preliminary analyses indicated that risk factors for non-recovery from PIF included lower physical fitness, female gender, severity of the acute sickness response, and autonomic dysfunction. Conclusions: COFFI (https://internationalcoffi.wordpress.com/) is an international collaboration which should be able to answer questions based on pooled data that are not answerable in the individual cohorts. Possible questions may include the following: Do different infections trigger different PIF syndromes (e.g. CFS vs. irritable bowel syndrome)?; What are longitudinal predictors of PIF and its severity?.",

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Katz, BZ, Collin, SM, Murphy, G, Moss-Morris, R, Wyller, VB, Wensaas, KA, Hautvast, JLA, Bleeker-Rovers, CP, Vollmer-Conna, U, Buchwald, D, Taylor, R, Little, P, Crawley, E, White, PD & Lloyd, A 2018, 'The international collaborative on fatigue following infection (COFFI)', Fatigue: Biomedicine, Health and Behavior, vol. 6, no. 2, pp. 106-121. https://doi.org/10.1080/21641846.2018.1426086

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AU - Katz, Ben Z.

AU - Collin, Simon M.

AU - Murphy, Gabrielle

AU - Moss-Morris, Rona

AU - Wyller, Vegard Bruun

AU - Wensaas, Knut Arne

AU - Hautvast, Jeannine L.A.

AU - Bleeker-Rovers, Chantal P.

AU - Vollmer-Conna, Ute

AU - Buchwald, Dedra

AU - Taylor, Renée

AU - Little, Paul

AU - Crawley, Esther

AU - White, Peter D.

AU - Lloyd, Andrew

PY - 2018/4/3

Y1 - 2018/4/3

N2 - Background: The purpose of the Collaborative on Fatigue Following Infection (COFFI) is for investigators of post-infection fatigue (PIF) and other syndromes to collaborate on these enigmatic and poorly understood conditions by studying relatively homogeneous populations with known infectious triggers. Utilising COFFI, pooled data and stored biosamples will support both epidemiological and laboratory research to better understand the etiology and risk factors for development and progression of PIF. Methods: COFFI consists of prospective cohorts from the UK, Netherlands, Norway, USA, New Zealand and Australia, with some cohorts closed and some open to recruitment. The 9 cohorts closed to recruitment total over 3000 participants, including nearly 1000 with infectious mononucleosis (IM), > 500 with Q fever, > 800 with giardiasis, > 600 with campylobacter gastroenteritis (CG), 190 with Legionnaires disease and 60 with Ross River virus. Follow-ups have been at least 6 months and up to 10 years. All studies use the Fukuda criteria for defining chronic fatigue syndrome (CFS). Results: Preliminary analyses indicated that risk factors for non-recovery from PIF included lower physical fitness, female gender, severity of the acute sickness response, and autonomic dysfunction. Conclusions: COFFI (https://internationalcoffi.wordpress.com/) is an international collaboration which should be able to answer questions based on pooled data that are not answerable in the individual cohorts. Possible questions may include the following: Do different infections trigger different PIF syndromes (e.g. CFS vs. irritable bowel syndrome)?; What are longitudinal predictors of PIF and its severity?.

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KW - Legionnaire's disease

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The international collaborative on fatigue following infection (COFFI)

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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